Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2361641..2362203 Replicon chromosome
Accession NZ_CP056229
Organism Citrobacter freundii strain RHBSTW-00968

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HV337_RS11200 Protein ID WP_096757033.1
Coordinates 2361925..2362203 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HV337_RS11195 Protein ID WP_096757032.1
Coordinates 2361641..2361925 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV337_RS11180 2356942..2359989 + 3048 WP_181491401.1 formate dehydrogenase-N subunit alpha -
HV337_RS11185 2360003..2360887 + 885 WP_115258486.1 formate dehydrogenase N subunit beta -
HV337_RS11190 2360880..2361536 + 657 WP_096757031.1 formate dehydrogenase-N subunit gamma -
HV337_RS11195 2361641..2361925 - 285 WP_096757032.1 HigA family addiction module antidote protein Antitoxin
HV337_RS11200 2361925..2362203 - 279 WP_096757033.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HV337_RS11205 2362391..2364106 - 1716 WP_181491402.1 ATP-binding cassette domain-containing protein -
HV337_RS11210 2364417..2366114 - 1698 WP_115258488.1 malate dehydrogenase -
HV337_RS11215 2366294..2366434 - 141 WP_096757036.1 stationary-phase-induced ribosome-associated protein -
HV337_RS11220 2366663..2367094 + 432 WP_096757037.1 OsmC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10601.05 Da        Isoelectric Point: 9.5320

>T163042 WP_096757033.1 NZ_CP056229:c2362203-2361925 [Citrobacter freundii]
MIMNFRHKGLRDLFLQGRTSGVTAKHVRRLRHRLAVIDAASHVTDINMPGYKLHALTGDRDGVWSISVSGNWRITFEFVN
GDAYILDYEDYH

Download         Length: 279 bp

>T163042 NZ_CP072298:2754-3110 [Acinetobacter baumannii]
ATGTGGACAGTCATTACGACAGATCTATTTAATGAATGGCTTGAACAGCAAGATGAATCAACACAAGAGAAGGTTTTAGC
TGCTTTGGTTGTTCTGCAACAACAGGGACCGAGCTTAGGCCGCCCTTTAGTAGATACCGTGTATGACTCTAAATTTACCA
ATATGAAAGAGCTTCGTGTTCAACATCGTGGTAAACCACTCCGAGCTTTTTTTGCATTTGATCCATTACGACAGGCCATT
GTGCTGTGTATTGGTGATAAAGGTGGTAAAAAGCGATTCTATACAGAGATGCTGGCGATTGCAGATCAACAATATGAACT
TCATCTCTCAACATTAGGAGAACAATCTAATGGCTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10327.05 Da        Isoelectric Point: 8.8094

>AT163042 WP_096757032.1 NZ_CP056229:c2361925-2361641 [Citrobacter freundii]
MKMANHPRPGDIIQEALDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPEMWLNLQNAWSLAEAQ
KSVDISRLRKLVAQ

Download         Length: 285 bp

>AT163042 NZ_CP072298:3103-3405 [Acinetobacter baumannii]
ATGGCTAAAACTTTGCAAGAATTATTAGCTAACCGCTCTCCAGAGAGCCAAGCCCGTATTCAAAAAATAGCTGATGAATT
GCTATTAGAAAATCAGCTTTACCTTATTCGTGAAGAACTCGAAATCTCTCAAAAAGAACTGGCTGAAACTTTGGGAATAA
AACAGCCATCACTTTCAGCAATAGAAAATCGTGGCAATGATCTTAAGATCTCAACCATGAAAAAGTATGTTGAAGCAATG
GGAGGGAAGCTCCGTATTGATGTAGAGCTTCCAACAGGAAAACATATAGGATTCAATGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References