Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 3930968..3931565 Replicon chromosome
Accession NZ_CP056222
Organism Klebsiella pneumoniae strain RHBSTW-00973

Toxin (Protein)


Gene name higB Uniprot ID R4YIC5
Locus tag HV338_RS19385 Protein ID WP_004142563.1
Coordinates 3931248..3931565 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID R4YH91
Locus tag HV338_RS19380 Protein ID WP_004142561.1
Coordinates 3930968..3931255 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV338_RS19350 3927048..3927296 + 249 WP_002893037.1 DUF1158 domain-containing protein -
HV338_RS19355 3927314..3927655 - 342 WP_002893035.1 RamA family antibiotic efflux transcriptional regulator -
HV338_RS19360 3927686..3928801 - 1116 WP_020316605.1 MBL fold metallo-hydrolase -
HV338_RS19365 3928981..3929562 + 582 WP_004176968.1 TetR/AcrR family transcriptional regulator -
HV338_RS19370 3929562..3929930 + 369 WP_004142557.1 MmcQ/YjbR family DNA-binding protein -
HV338_RS19375 3930050..3930703 + 654 WP_004178896.1 oxygen-insensitive NAD(P)H nitroreductase -
HV338_RS19380 3930968..3931255 - 288 WP_004142561.1 helix-turn-helix transcriptional regulator Antitoxin
HV338_RS19385 3931248..3931565 - 318 WP_004142563.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HV338_RS19390 3931750..3932793 - 1044 WP_048988693.1 DUF2157 domain-containing protein -
HV338_RS19395 3933459..3934325 - 867 WP_004151823.1 helix-turn-helix transcriptional regulator -
HV338_RS19400 3934434..3935861 + 1428 WP_009308097.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-88)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12110.39 Da        Isoelectric Point: 11.2767

>T163020 WP_004142563.1 NZ_CP056222:c3931565-3931248 [Klebsiella pneumoniae]
MFRLVVHVDVKKELQALPPIVQAKMIRQLDKLRQNPTALREPDSKPLGQGLFEIRALGSVQGRGIYVFQQGKTLFLLRVF
VKKTQKTPSSEIRLALKRLEEMRNE

Download         Length: 318 bp

>T163020 NZ_CP072275:c2955635-2955453 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
TAAACACCCAACCAAAAAGGGGTTAGTTACAATCCCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAACAAGCGGGTCTAAATTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10771.46 Da        Isoelectric Point: 10.2212

>AT163020 WP_004142561.1 NZ_CP056222:c3931255-3930968 [Klebsiella pneumoniae]
MSKKIIDWDTLKTELLGQPEVQAAFDAQERQQRLRTMLAQWREQAGLTRAQVAQRMGVSAPTVSRMEANITRASLDTLTR
YALACGIKHPQVLLY

Download         Length: 288 bp

>AT163020 NZ_CP072275:c2955360-2954956 [Acinetobacter baumannii]
ATGTTATATCCAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGCCATTTAGAAATATTGGCTGAAG
ATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGATCCTGAATATAAAGGAATGATCTGGGCGGTT
ACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M5MXH8

Antitoxin

Source ID Structure
AlphaFold DB A0A0S3DIQ1

References