Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 3737234..3737831 Replicon chromosome
Accession NZ_CP056216
Organism Klebsiella pneumoniae strain RHBSTW-00982

Toxin (Protein)


Gene name higB Uniprot ID A0A9J6S5A1
Locus tag HV343_RS18275 Protein ID WP_004893639.1
Coordinates 3737514..3737831 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID R4YH91
Locus tag HV343_RS18270 Protein ID WP_004142561.1
Coordinates 3737234..3737521 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV343_RS18240 3733441..3733689 + 249 WP_002893037.1 DUF1158 domain-containing protein -
HV343_RS18245 3733707..3734048 - 342 WP_002893035.1 RamA family antibiotic efflux transcriptional regulator -
HV343_RS18250 3734079..3735194 - 1116 WP_012737592.1 MBL fold metallo-hydrolase -
HV343_RS18255 3735374..3735955 + 582 WP_004176968.1 TetR/AcrR family transcriptional regulator -
HV343_RS18260 3735955..3736323 + 369 WP_004142557.1 MmcQ/YjbR family DNA-binding protein -
HV343_RS18265 3736443..3737096 + 654 WP_004178896.1 oxygen-insensitive NAD(P)H nitroreductase -
HV343_RS18270 3737234..3737521 - 288 WP_004142561.1 helix-turn-helix transcriptional regulator Antitoxin
HV343_RS18275 3737514..3737831 - 318 WP_004893639.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HV343_RS18280 3738016..3739059 - 1044 WP_023279204.1 DUF2157 domain-containing protein -
HV343_RS18285 3739729..3740595 - 867 WP_004151823.1 helix-turn-helix transcriptional regulator -
HV343_RS18290 3740704..3742131 + 1428 WP_004176980.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-88)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12100.35 Da        Isoelectric Point: 11.2767

>T163001 WP_004893639.1 NZ_CP056216:c3737831-3737514 [Klebsiella pneumoniae]
MFRLVVHVDVKKELQALPSIVQAKMIRQLDKLRQNPTALREPDSKPLGQGLFEIRALGSVQGRGIYVFQQGKTLFLLRVF
VKKTQKTPSSEIRLALKRLEEMRNE

Download         Length: 318 bp

>T163001 NZ_CP072263:c4801382-4801230 [Xanthomonas citri pv. glycines CFBP 2526]
ATGAAGCGACTGCTGACACTGATGGTGCTGGGCCTGTTTTCGGCCGGCGTGATGACGGGCTGCAACACCGTGGCCGGCGC
CGGCAAGGACATGCAGGGTGCGGGCAACAAGGTCGAGAAAACGGCCGAAAAATGCAGCGACGGTAAGTGCTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10771.46 Da        Isoelectric Point: 10.2212

>AT163001 WP_004142561.1 NZ_CP056216:c3737521-3737234 [Klebsiella pneumoniae]
MSKKIIDWDTLKTELLGQPEVQAAFDAQERQQRLRTMLAQWREQAGLTRAQVAQRMGVSAPTVSRMEANITRASLDTLTR
YALACGIKHPQVLLY

Download         Length: 288 bp

>AT163001 NZ_CP072263:c4801155-4801021 [Xanthomonas citri pv. glycines CFBP 2526]
ATGAAGCGTGCAATTGTGCTGCTGGTGCTGTCGATGTTGTCGGTGGGAATGTTGGCGGGTTGCAACACCGTCGCAGGTGC
CGGCAAGGACGTGCAGGGCGCCGGCGAGAAGGTGGAAGACGCAGCGCGTAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0S3DIQ1

References