Detailed information of TA system TA162967

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 3003538..3004174
• Replicon: chromosome
• Accession: NZ_CP056199
• Organism: Enterobacter sp. RHBSTW-00994

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A7L6CLM4
• Locus tag: HV346_RS14535
• Protein ID: WP_001607612.1
• Coordinates: 3003845..3004174 (-)
• Length: 110 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: HV346_RS14530
• Protein ID: WP_001553123.1
• Coordinates: 3003538..3003840 (-)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2980271..3004916	24645

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (5-98)

Antitoxin

• Cro/C1-type helix-turn-helix domain (33-81)

Sequences

Toxin

Protein

• Length: 110 a.a.
• Molecular weight: 12529.28 Da
• Isoelectric Point: 8.9627

>T162967 WP_001607612.1 NZ_CP056199:c3004174-3003845 [Enterobacter sp. RHBSTW-00994]
MFDHWFTSLNDTDRASVLAALLVLREKGPGLSRPYADTIRGSRYSNMKELRIQSRGDPIRAFFAFDPARTGIVLCAGNKV
GNEKRFYDEMLPIADREFTNWLNTLKEKE

Nucleotide

• Length: 330 bp

>T162967 NZ_CP072203:c691936-691646 [Gordonia polyisoprenivorans]
ATGAGCGAGGACCCCGGCTGCTCGCCCGACCCGTACCGGGTCGAGGTCGCATCCCCAGCCCGTCGCGACCTCGAGCGACT
CCCCTCCCGGATCGTCCACGCCGTCATCGAGTTCATCTCCGGCCCCCTTGCCGAAAACCCCCACCGGCTCGGCAAGCCGT
TGCGCGACCAACTCGAAGGCCTCCGTAGTGCCCGCCGCGGCGACTATCGCATCCTGCTCCGCATCGACGATTCCGGCCAC
ACGATCATCATCGTCAGAATCGACCACCGCGCTCACGCCTACCGCGCCTGA

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 11084.82 Da
• Isoelectric Point: 5.1786

>AT162967 WP_001553123.1 NZ_CP056199:c3003840-3003538 [Enterobacter sp. RHBSTW-00994]
MGRTLEQLIADEKPEVVDEAQAMATDILLNIHLAELREKVQKTQVEMAQALGIRQPTVAGMEKPGRDLKLSTLKRYVEAT
GGKLRLDVELPDGSHYGFVL

Nucleotide

• Length: 303 bp

>AT162967 NZ_CP072203:c692208-691933 [Gordonia polyisoprenivorans]
ATGACGACAGTGCCACTCGGTGAAGCCAAGGACAAGCTCTCGGCGCTCATCGACAGCGCCGCGACCACGCACGACATCAT
CACGATCACCAAACACGGCAAACCGGCTGCGGTGCTCATGTCGGCCGACGACCTCGAATCGCTGCACGAGACGATCTACT
GGCTCTCGAGGTCCGGGACCCGCGACGACATGGCTACTGCCGACGCCGAGTACTCGGCCGGCCACACGACTTCTCTCGAG
GATTTGCGCGCCGAACACGGCATGCCGCCCGAATGA

Structures

Toxin

• AlphaFold DB: A0A7L6CLM4