Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2353851..2354413 Replicon chromosome
Accession NZ_CP056165
Organism Escherichia marmotae strain RHBSTW-00777

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HV276_RS11225 Protein ID WP_105225028.1
Coordinates 2353851..2354129 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID S1PAQ1
Locus tag HV276_RS11230 Protein ID WP_000781370.1
Coordinates 2354129..2354413 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV276_RS11200 2349471..2349902 - 432 WP_181503326.1 peroxiredoxin OsmC -
HV276_RS11205 2350225..2350440 + 216 WP_000495761.1 biofilm-dependent modulation protein -
HV276_RS11210 2350531..2350668 + 138 WP_000841554.1 stationary-phase-induced ribosome-associated protein -
HV276_RS11215 2350824..2352521 + 1698 WP_001516384.1 malate dehydrogenase -
HV276_RS11220 2352655..2353665 + 1011 WP_000642389.1 alcohol dehydrogenase AdhP -
HV276_RS11225 2353851..2354129 + 279 WP_105225028.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HV276_RS11230 2354129..2354413 + 285 WP_000781370.1 HigA family addiction module antidote protein Antitoxin
HV276_RS11235 2354640..2355293 - 654 WP_000045637.1 formate dehydrogenase-N subunit gamma -
HV276_RS11240 2355286..2356170 - 885 WP_001240589.1 formate dehydrogenase N subunit beta -
HV276_RS11245 2356183..2359230 - 3048 WP_077633351.1 formate dehydrogenase-N subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-88)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10616.19 Da        Isoelectric Point: 6.0583

>T162862 WP_105225028.1 NZ_CP056165:2353851-2354129 [Escherichia marmotae]
MIMNFRHKGLRDLFLLGKTSGVMPTQVKRLRHRLAVIDAASCLADIDMPGYRLHPLSGDCDEIWAISVSDNWRITFEFVN
GDAYILDYEDYH

Download         Length: 279 bp

>T162862 NZ_CP072146:140806-141051 [Rhizobium sp. K1/93]
ATGAAGGACGTTGTCGTATCCCGACTTGCCGACAAAGCACTTATGCGCATGCAGCCAAAACGGCGGCTGGCGATTATTGA
AAAAGTCAAAGCCTATGCGCGCGGAGAGATTGTCGACATCAAGAAGATGAAAGGCGGAAATCTCTACCGTATCAGGGTCG
GACAGGATCGCGTCATCATCGACGACAAGGGTAGGATTGTCGTGGTCATCGATGCCGGTCCGCGGGGCAGTATCTACAAG
GAGTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10401.08 Da        Isoelectric Point: 8.8567

>AT162862 WP_000781370.1 NZ_CP056165:2354129-2354413 [Escherichia marmotae]
MKMANHPRPGDIIQESLDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPQMWLNLQNAWSLAEAE
KTVDVSRLRRLVTQ

Download         Length: 285 bp

>AT162862 NZ_CP072146:141058-141420 [Rhizobium sp. K1/93]
ATGGGCGATATCAAGAGGTTCGAAATCGACGGCAAACCCTATGTGCTGTTGAGTGAAGAGGATTATGAGGATCTCGTCGA
TGGACTGAGGGCGAATGCTGTCCTGGCCGGGATTTCTGCAGGAGAAGAAACCTGGCCCTTGGAGATCGTTGAGGCGCGTG
CCAATGGCGGAAATGCCGTTCGTATCTTCCGAAACTATCGCCGCATGACTGTTACCGAACTTGCCACGGCCGCCGGAATT
TCGCAGCCCTATCTCTCTGAGATCGAGGCAGGCAAAAAAACCGGCAGTGTCGATGTCCTGAAGCGTATCGCTAACGCCCT
CAAGGTCGATCTCGACGATCTCGTCGTCAACGTGGCGGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 2ICT
PDB 2ICP
AlphaFold DB A0A829CUG6

References