Detailed information of TA system TA162848

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 705582..705840
• Replicon: chromosome
• Accession: NZ_CP056165
• Organism: Escherichia marmotae strain RHBSTW-00777

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: -
• Locus tag: HV276_RS03355
• Protein ID: WP_000935262.1
• Coordinates: 705582..705791 (-)
• Length: 70 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	705783..705840 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HV276_RS03335	700907..701473	-	567	WP_000528538.1	acetate uptake transporter	-
HV276_RS03340	701713..701965	-	253	Protein_645	DUF2541 family protein	-
HV276_RS03345	702342..704258	+	1917	WP_000516135.1	molecular chaperone DnaK	-
HV276_RS03350	704347..705477	+	1131	WP_181503166.1	molecular chaperone DnaJ	-
HV276_RS03355	705582..705791	-	210	WP_000935262.1	type I toxin-antitoxin system Hok family toxin	Toxin
-	705783..705840	+	58	-	-	Antitoxin
HV276_RS03360	706318..707484	+	1167	WP_000681378.1	Na+/H+ antiporter NhaA	-
HV276_RS03365	707544..708449	+	906	WP_000062876.1	transcriptional activator NhaR	-
HV276_RS03370	708552..708815	-	264	WP_001274018.1	30S ribosomal protein S20	-
HV276_RS03375	708918..709136	+	219	Protein_652	DUF2575 domain-containing protein	-
HV276_RS03380	709144..710085	+	942	WP_000767344.1	bifunctional riboflavin kinase/FAD synthetase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (25-66)

Sequences

Toxin

Protein

• Length: 70 a.a.
• Molecular weight: 7742.28 Da
• Isoelectric Point: 9.3680

>T162848 WP_000935262.1 NZ_CP056165:c705791-705582 [Escherichia marmotae]
MLNTCRVPLTDRKVKEKRAMKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 210 bp

>T162848 NZ_CP072141:c2194046-2193750 [Rhizobium sp. L51/94]
ATGCCCTTGGAAACCACCCGCTTTGACATCCAGGACCATTTGACCACACCGGCCGACCGCATGCTCTATCTCGAAGCCGC
TTTCGAGGACGGTGATCCGGCGCTCATCACCCAGGCCCTCGGCGACGTTGCCCGTGCTGCCGGCATGACGTCTGTCGCCA
AAGAAGCGGGCGTGACCCGGGAAGCACTCTATAAATCACTGAGCGAAGCCGGTGATCCGCGCTTGTCGACCTTTCTCGGC
GTGATCAAGGCGCTAGGATTGAAGGTGTCGATCTCGACGGATCAGAATGCGGCTTAG

Antitoxin

Nucleotide

• Length: 58 bp

>AT162848 NZ_CP056165:705783-705840 [Escherichia marmotae]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Antitoxin