Detailed information of TA system TA162846

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): symE-sokC/SymE(toxin)
• Location: 626801..627213
• Replicon: chromosome
• Accession: NZ_CP056165
• Organism: Escherichia marmotae strain RHBSTW-00777

Toxin (Protein)

• Gene name: symE
• Uniprot ID: A0A7L6L4L5
• Locus tag: HV276_RS02980
• Protein ID: WP_033873755.1
• Coordinates: 626801..627142 (-)
• Length: 114 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	627137..627213 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HV276_RS02960	623255..624199	+	945	WP_181503163.1	Rpn family recombination-promoting nuclease/putative transposase	-
HV276_RS02965	624401..624565	+	165	Protein_573	DUF1127 domain-containing protein	-
HV276_RS02970	624661..625540	+	880	Protein_574	DUF262 domain-containing protein	-
HV276_RS02975	625591..626754	+	1164	WP_181503330.1	DUF262 and DUF1524 domain-containing protein	-
HV276_RS02980	626801..627142	-	342	WP_033873755.1	endoribonuclease SymE	Toxin
-	627137..627213	+	77	NuclAT_5	-	Antitoxin
-	627137..627213	+	77	NuclAT_5	-	Antitoxin
-	627137..627213	+	77	NuclAT_5	-	Antitoxin
-	627137..627213	+	77	NuclAT_5	-	Antitoxin
-	627137..627213	+	77	NuclAT_6	-	Antitoxin
-	627137..627213	+	77	NuclAT_6	-	Antitoxin
-	627137..627213	+	77	NuclAT_6	-	Antitoxin
-	627137..627213	+	77	NuclAT_6	-	Antitoxin
HV276_RS02985	627363..629114	-	1752	WP_180563289.1	restriction endonuclease subunit S	-
HV276_RS02990	629114..630583	-	1470	WP_016159453.1	type I restriction-modification system subunit M	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (20-71)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12296.10 Da
• Isoelectric Point: 7.8219

>T162846 WP_033873755.1 NZ_CP056165:c627142-626801 [Escherichia marmotae]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPAAEESE
LMQSLRQVCKLSARKQKQVQEFIGVIAGKQKVA

Nucleotide

• Length: 342 bp

>T162846 NZ_CP072141:1766162-1766434 [Rhizobium sp. L51/94]
ATGGCGTGGAGGATTGAGTTCCAGCGGTCAGCGGAACGCGATCTTGAAAAGCTCGACCATGAGAGCGTGAAAAGGATACT
CCGTTTCCTTCACACCCGTGTCGCCAGCCTCGAGGACCCCCGGTCGATAGGGGAGGCGCTTCGCGGATCGGAACTTGGAA
ACTTCTGGAAGTATCGTGTTGGAGACTATCGCATCATTGTCGACATAGACGACGGCACTGTCCGGATATTGGTCGTCCGC
ATTGGCAATCGGAAGGACGTCTATCGCCGCTGA

Antitoxin

Nucleotide

• Length: 77 bp

>AT162846 NZ_CP056165:627137-627213 [Escherichia marmotae]
AGTCATAACTGCTATTCTCCTGGAATAGTGATTGTGATGAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGTGCT

Structures

Toxin

• AlphaFold DB: A0A7L6L4L5

Antitoxin