Detailed information of TA system TA162830

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 758919..759131
• Replicon: chromosome
• Accession: NZ_CP056159
• Organism: Escherichia marmotae strain RHBSTW-00814

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: -
• Locus tag: HV284_RS03845
• Protein ID: WP_000543831.1
• Coordinates: 758919..759131 (-)
• Length: 71 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	759086..759116 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HV284_RS03795	754023..754208	-	186	WP_181474751.1	Rz1 family lipoprotein	-
HV284_RS03800	754425..754829	-	405	WP_181474752.1	lysozyme	-
HV284_RS03805	754935..755207	+	273	WP_001315200.1	hypothetical protein	-
HV284_RS03810	755173..755517	-	345	WP_000193257.1	YdfR family protein	-
HV284_RS03815	755522..755737	-	216	WP_000839600.1	phage lysis protein EssD	-
HV284_RS03830	757024..757566	-	543	WP_181474753.1	DUF1133 family protein	-
HV284_RS03835	757563..757853	-	291	WP_181474754.1	DUF1364 domain-containing protein	-
HV284_RS03840	757853..758452	-	600	WP_000940322.1	DUF1367 family protein	-
HV284_RS03845	758919..759131	-	213	WP_000543831.1	type I toxin-antitoxin system Hok family toxin	Toxin
-	759086..759116	+	31	-	-	Antitoxin
HV284_RS03850	760036..760425	-	390	WP_181474755.1	hypothetical protein	-
HV284_RS03855	760715..760957	-	243	Protein_761	ead/Ea22-like family protein	-
HV284_RS03860	760954..761370	-	417	WP_181474756.1	DUF977 family protein	-
HV284_RS03865	761386..762147	-	762	WP_000450696.1	DUF1627 domain-containing protein	-
HV284_RS03870	762170..762916	-	747	WP_101917241.1	ATP-binding protein	-
HV284_RS03875	762923..763779	-	857	Protein_765	DUF1376 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	727403..773235	45832

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (25-66)

Sequences

Toxin

Protein

• Length: 71 a.a.
• Molecular weight: 7904.40 Da
• Isoelectric Point: 8.5140

>T162830 WP_000543831.1 NZ_CP056159:c759131-758919 [Escherichia marmotae]
MHDNIRLASYVPKGKEKQAMKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 213 bp

>T162830 NZ_CP072130:825547-825957 [Klebsiella variicola]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTCCACGGCGTTGTGGCGGC
GCTGGTGCTGTTGGTTCCCTGGCCGCTAAGCTACACCCCGATCTGGCTGCTGCTGTTGTCGCTGGTAGTGTTTGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGAGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTCATCAATAGCGGTATGCTGCTGCGTTTACGCCATGTCGATACCCGGCGCGG
GCAGCATCTGTGGCTGGCGGCGGATAGCATGGATGCCGGAGAATGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin

Nucleotide

• Length: 31 bp

>AT162830 NZ_CP056159:759086-759116 [Escherichia marmotae]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCT

Structures

Antitoxin