Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 626859..627421 Replicon chromosome
Accession NZ_CP056159
Organism Escherichia marmotae strain RHBSTW-00814

Toxin (Protein)


Gene name higB Uniprot ID A0A7H9K4H3
Locus tag HV284_RS03205 Protein ID WP_001516386.1
Coordinates 626859..627137 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID S1PAQ1
Locus tag HV284_RS03210 Protein ID WP_000781370.1
Coordinates 627137..627421 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV284_RS03180 622479..622910 - 432 WP_000152293.1 peroxiredoxin OsmC -
HV284_RS03185 623233..623448 + 216 WP_000495761.1 biofilm-dependent modulation protein -
HV284_RS03190 623539..623676 + 138 WP_000841554.1 stationary-phase-induced ribosome-associated protein -
HV284_RS03195 623832..625529 + 1698 WP_001516384.1 malate dehydrogenase -
HV284_RS03200 625663..626673 + 1011 WP_000642389.1 alcohol dehydrogenase AdhP -
HV284_RS03205 626859..627137 + 279 WP_001516386.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HV284_RS03210 627137..627421 + 285 WP_000781370.1 HigA family addiction module antidote protein Antitoxin
HV284_RS03215 627649..628302 - 654 WP_000045637.1 formate dehydrogenase-N subunit gamma -
HV284_RS03220 628295..629179 - 885 WP_001240589.1 formate dehydrogenase N subunit beta -
HV284_RS03225 629192..632239 - 3048 WP_077633351.1 formate dehydrogenase-N subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-88)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10623.19 Da        Isoelectric Point: 6.8682

>T162828 WP_001516386.1 NZ_CP056159:626859-627137 [Escherichia marmotae]
MIMNFRHKGLRDLFLLGKTSGVIPTQVKRLRHRLAVIDAASCLADIDMPGYRLHPLSGDRDEIWTISVSGNWRLTFEFVN
GDAYILDYEDYH

Download         Length: 279 bp

>T162828 NZ_CP072130:328662-329030 [Klebsiella variicola]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGACCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCACCTGCTGGCGATTTCTCGCGGCCATATTTTCAATGATGGAAATAAGCGTACGGCACTGTTT
ATTACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCGGCGAACCCGGACTTCGTCGGCATGACCGTCGAGGCGGC
AGCGGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGCGGATGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10401.08 Da        Isoelectric Point: 8.8567

>AT162828 WP_000781370.1 NZ_CP056159:627137-627421 [Escherichia marmotae]
MKMANHPRPGDIIQESLDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPQMWLNLQNAWSLAEAE
KTVDVSRLRRLVTQ

Download         Length: 285 bp

>AT162828 NZ_CP072130:328444-328665 [Klebsiella variicola]
ATGAAAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAATTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATTATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7H9K4H3

Antitoxin

Source ID Structure
PDB 2ICT
PDB 2ICP
AlphaFold DB A0A829CUG6

References