Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/COG4683-HTH_37 |
Location | 2200112..2200772 | Replicon | chromosome |
Accession | NZ_CP056150 | ||
Organism | Klebsiella grimontii strain RHBSTW-00853 |
Toxin (Protein)
Gene name | higB | Uniprot ID | - |
Locus tag | HV299_RS10620 | Protein ID | WP_049130929.1 |
Coordinates | 2200112..2200465 (+) | Length | 118 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | A0A9E1DQ94 |
Locus tag | HV299_RS10625 | Protein ID | WP_004132739.1 |
Coordinates | 2200470..2200772 (+) | Length | 101 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
HV299_RS10595 | 2195496..2196263 | - | 768 | WP_004132727.1 | molybdopterin-dependent oxidoreductase | - |
HV299_RS10600 | 2196253..2196861 | - | 609 | WP_004132729.1 | cytochrome b/b6 domain-containing protein | - |
HV299_RS10605 | 2196876..2197502 | - | 627 | WP_154915551.1 | hypothetical protein | - |
HV299_RS10610 | 2197642..2198310 | + | 669 | WP_004132733.1 | heavy metal response regulator transcription factor | - |
HV299_RS10615 | 2198310..2199728 | + | 1419 | WP_154915550.1 | heavy metal sensor histidine kinase | - |
HV299_RS10620 | 2200112..2200465 | + | 354 | WP_049130929.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
HV299_RS10625 | 2200470..2200772 | + | 303 | WP_004132739.1 | XRE family transcriptional regulator | Antitoxin |
HV299_RS10630 | 2200966..2201169 | + | 204 | Protein_2086 | hypothetical protein | - |
HV299_RS10635 | 2201170..2201502 | + | 333 | WP_024359977.1 | type II toxin-antitoxin system PemK/MazF family toxin | - |
HV299_RS10645 | 2201825..2203282 | + | 1458 | WP_004136541.1 | EmmdR/YeeO family multidrug/toxin efflux MATE transporter | - |
HV299_RS10655 | 2204310..2205764 | - | 1455 | WP_049089250.1 | AMP nucleosidase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 118 a.a. Molecular weight: 13580.62 Da Isoelectric Point: 10.3329
>T162776 WP_049130929.1 NZ_CP056150:2200112-2200465 [Klebsiella grimontii]
VWMIKTTDTFERWFTSLNDTDRARVLAALLVLREKGPGLSRPYADTLRGSRYSNMKELRIQSRGEPIRAFFAFGPARTGI
VLCAGNKVGNEKRFYDEMLPVAEREFTNWLKTFKEKE
VWMIKTTDTFERWFTSLNDTDRARVLAALLVLREKGPGLSRPYADTLRGSRYSNMKELRIQSRGEPIRAFFAFGPARTGI
VLCAGNKVGNEKRFYDEMLPVAEREFTNWLKTFKEKE
Download Length: 354 bp
>T162776 NZ_CP072054:4334037-4334387 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACACGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACACGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA
Antitoxin
Download Length: 101 a.a. Molecular weight: 11072.83 Da Isoelectric Point: 5.7424
>AT162776 WP_004132739.1 NZ_CP056150:2200470-2200772 [Klebsiella grimontii]
MGRTLEQLMADEKPEVVADARAMAADILLNIHLAELREKVQKTQVEMAQALGIRQPTVAGMEKPGRDLKLSTLKRYVEAT
GGKLRLDVELPDGSHYGFEL
MGRTLEQLMADEKPEVVADARAMAADILLNIHLAELREKVQKTQVEMAQALGIRQPTVAGMEKPGRDLKLSTLKRYVEAT
GGKLRLDVELPDGSHYGFEL
Download Length: 303 bp
>AT162776 NZ_CP072054:4333792-4334043 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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