Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2200112..2200772 Replicon chromosome
Accession NZ_CP056150
Organism Klebsiella grimontii strain RHBSTW-00853

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HV299_RS10620 Protein ID WP_049130929.1
Coordinates 2200112..2200465 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A9E1DQ94
Locus tag HV299_RS10625 Protein ID WP_004132739.1
Coordinates 2200470..2200772 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV299_RS10595 2195496..2196263 - 768 WP_004132727.1 molybdopterin-dependent oxidoreductase -
HV299_RS10600 2196253..2196861 - 609 WP_004132729.1 cytochrome b/b6 domain-containing protein -
HV299_RS10605 2196876..2197502 - 627 WP_154915551.1 hypothetical protein -
HV299_RS10610 2197642..2198310 + 669 WP_004132733.1 heavy metal response regulator transcription factor -
HV299_RS10615 2198310..2199728 + 1419 WP_154915550.1 heavy metal sensor histidine kinase -
HV299_RS10620 2200112..2200465 + 354 WP_049130929.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HV299_RS10625 2200470..2200772 + 303 WP_004132739.1 XRE family transcriptional regulator Antitoxin
HV299_RS10630 2200966..2201169 + 204 Protein_2086 hypothetical protein -
HV299_RS10635 2201170..2201502 + 333 WP_024359977.1 type II toxin-antitoxin system PemK/MazF family toxin -
HV299_RS10645 2201825..2203282 + 1458 WP_004136541.1 EmmdR/YeeO family multidrug/toxin efflux MATE transporter -
HV299_RS10655 2204310..2205764 - 1455 WP_049089250.1 AMP nucleosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-81)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13580.62 Da        Isoelectric Point: 10.3329

>T162776 WP_049130929.1 NZ_CP056150:2200112-2200465 [Klebsiella grimontii]
VWMIKTTDTFERWFTSLNDTDRARVLAALLVLREKGPGLSRPYADTLRGSRYSNMKELRIQSRGEPIRAFFAFGPARTGI
VLCAGNKVGNEKRFYDEMLPVAEREFTNWLKTFKEKE

Download         Length: 354 bp

>T162776 NZ_CP072054:4334037-4334387 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACACGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11072.83 Da        Isoelectric Point: 5.7424

>AT162776 WP_004132739.1 NZ_CP056150:2200470-2200772 [Klebsiella grimontii]
MGRTLEQLMADEKPEVVADARAMAADILLNIHLAELREKVQKTQVEMAQALGIRQPTVAGMEKPGRDLKLSTLKRYVEAT
GGKLRLDVELPDGSHYGFEL

Download         Length: 303 bp

>AT162776 NZ_CP072054:4333792-4334043 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References