Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 4031225..4031822 Replicon chromosome
Accession NZ_CP056145
Organism Klebsiella variicola strain RHBSTW-00883

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HV312_RS19530 Protein ID WP_181481662.1
Coordinates 4031505..4031822 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HV312_RS19525 Protein ID WP_148273984.1
Coordinates 4031225..4031512 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV312_RS19495 4027130..4027378 + 249 WP_008805539.1 DUF1158 domain-containing protein -
HV312_RS19500 4027395..4027736 - 342 WP_002893035.1 RamA family antibiotic efflux transcriptional regulator -
HV312_RS19505 4027767..4028882 - 1116 WP_162493283.1 MBL fold metallo-hydrolase -
HV312_RS19510 4029062..4029643 + 582 WP_017899014.1 TetR/AcrR family transcriptional regulator -
HV312_RS19515 4029643..4030011 + 369 WP_008805536.1 MmcQ/YjbR family DNA-binding protein -
HV312_RS19520 4030131..4030784 + 654 WP_012968755.1 oxygen-insensitive NAD(P)H nitroreductase -
HV312_RS19525 4031225..4031512 - 288 WP_148273984.1 helix-turn-helix transcriptional regulator Antitoxin
HV312_RS19530 4031505..4031822 - 318 WP_181481662.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HV312_RS19535 4032007..4033050 - 1044 WP_023297181.1 hypothetical protein -
HV312_RS19540 4033714..4034583 - 870 WP_061155431.1 helix-turn-helix transcriptional regulator -
HV312_RS19545 4034692..4036119 + 1428 WP_181481663.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-89)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12166.49 Da        Isoelectric Point: 11.1140

>T162752 WP_181481662.1 NZ_CP056145:c4031822-4031505 [Klebsiella variicola]
MFRLVVHVDVKKELQALPPIVQAKMIWQIDKLRQNPTALREPDSKPLGQGLFEIRALGLVQGRGIYVFQQGKTLFLLRVF
VKKTQKTPSSEIRLALKRLEEMRNE

Download         Length: 318 bp

>T162752 NZ_CP072054:c246238-245960 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATATTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10757.47 Da        Isoelectric Point: 10.5481

>AT162752 WP_148273984.1 NZ_CP056145:c4031512-4031225 [Klebsiella variicola]
MSKKIIDWDTLKTELLSQPEVQAAFGAQERQQRLRTMLAQWREQAGLTRAQVAQRMGVSAPTVSRMEANITRASLDTLTR
YALACGIKHPQILLY

Download         Length: 288 bp

>AT162752 NZ_CP072054:c246501-246241 [Escherichia coli]
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCAGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCATTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References