Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 92368..93014 Replicon chromosome
Accession NZ_CP056132
Organism Enterobacter hormaechei strain RHBSTW-00916

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HV326_RS00475 Protein ID WP_047050720.1
Coordinates 92664..93014 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A7H8UAV4
Locus tag HV326_RS00470 Protein ID WP_045335986.1
Coordinates 92368..92667 (-) Length 100 a.a.

Genomic Context

HV326_RS00455HV326_RS00460HV326_RS00465HV326_RS00490HV326_RS00445HV326_RS00450HV326_RS00470HV326_RS00475HV326_RS00480HV326_RS00485HV326_RS00495HV326_RS00500HV326_RS00505HV326_RS00510
Location: 89910..90698 (789 bp)
Type: Others
Protein ID: WP_045329485.1
Location: 90700..91179 (480 bp)
Type: Others
Protein ID: WP_047050718.1
Location: 91422..92303 (882 bp)
Type: Others
Protein ID: WP_047050719.1
Location: 94120..94296 (177 bp)
Type: Others
Protein ID: WP_071962261.1
Location: 87836..88420 (585 bp)
Type: Others
Protein ID: WP_023299002.1
Location: 88473..89075 (603 bp)
Type: Others
Protein ID: WP_047050717.1
Location: 92368..92667 (300 bp)
Type: Antitoxin
Protein ID: WP_045335986.1
Location: 92664..93014 (351 bp)
Type: Toxin
Protein ID: WP_047050720.1
Location: 93287..93539 (253 bp)
Type: Others
Protein ID: Protein_95
Location: 93642..93983 (342 bp)
Type: Others
Protein ID: WP_006812446.1
Location: 94336..95892 (1557 bp)
Type: Others
Protein ID: WP_047050722.1
Location: 96187..96507 (321 bp)
Type: Others
Protein ID: WP_059443702.1
Location: 96528..96854 (327 bp)
Type: Others
Protein ID: WP_059443453.1
Location: 96867..97337 (471 bp)
Type: Others
Protein ID: WP_015703840.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
HV326_RS0044587836..88420-585WP_023299002.1type 1 fimbrial protein-
HV326_RS0045088473..89075-603WP_047050717.1response regulator transcription factor-
HV326_RS0045589910..90698+789WP_045329485.1winged helix-turn-helix domain-containing protein-
HV326_RS0046090700..91179+480WP_047050718.1hypothetical protein-
HV326_RS0046591422..92303+882WP_047050719.1helix-turn-helix domain-containing protein-
HV326_RS0047092368..92667-300WP_045335986.1XRE family transcriptional regulatorAntitoxin
HV326_RS0047592664..93014-351WP_047050720.1type II toxin-antitoxin system RelE/ParE family toxinToxin
HV326_RS0048093287..93539-253Protein_95DNA-binding protein-
HV326_RS0048593642..93983-342WP_006812446.1SymE family type I addiction module toxin-
HV326_RS0049094120..94296+177WP_071962261.1toxin-antitoxin system HicB family antitoxin-
HV326_RS0049594336..95892-1557WP_047050722.1hypothetical protein-
HV326_RS0050096187..96507-321WP_059443702.1TA system toxin CbtA family protein-
HV326_RS0050596528..96854-327WP_059443453.1type IV toxin-antitoxin system YeeU family antitoxin-
HV326_RS0051096867..97337-471WP_015703840.1DNA repair protein RadC-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic island--89910..11114221232


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-105)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-88)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13497.59 Da        Isoelectric Point: 8.8416

>T162716 WP_047050720.1 NZ_CP056132:c93014-92664 [Enterobacter hormaechei]
MWTVLFSKVFEQWLLEQEDGLQEKVLADLLNLQNYGPRLPRPYADTVKGSQYKNMKELRIQYAGRPVRAFFAFDPVRQAI
VLCAGDKRNDKTFYEKLIRIADAEFTLHLTSLEAAK

Download         Length: 351 bp

>T162716 NZ_CP071974:2139865-2140125 [Trueperella pecoris]
GTGAGCTATCGCGTTGAACTAACAACAGCCGCTGCTCGCCAGATTAAGAAACTGCCTCACGAAGCACGCGGTCGCATTTT
GGACGCGCTAGAGAAATTGGCGGACGATCCTCGGCCCCGCGGCGCAAAGAAGCTTGTCGGCGAACAGAATGCATGGCGAA
TTCGCCTCGGAGATTACCGAATTATTTATGACATCTTTGACGACATACTGACTGTAACAATCGTTCGCGCTGGGCATCGT
CGCGAAATTTACCGCAGCTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11129.87 Da        Isoelectric Point: 6.4714

>AT162716 WP_045335986.1 NZ_CP056132:c92667-92368 [Enterobacter hormaechei]
VKTLNEVIASRSPESQQRIQEMAEEMFLETGLQLLREELQLSQKHVADLMGVSQPAVTQLEQRGNDLKIATLKRYIEAMG
GKLSINVELPTGKRVAFHL

Download         Length: 300 bp

>AT162716 NZ_CP071974:2139605-2139868 [Trueperella pecoris]
ATGAACACGATCACCAGCGAGGTCTCGACTCGCGAACTACGCAGCCAGCTCTCAGACGTTCTTGGGCGGGCCATGTACGC
CGGCGAACGCATCGGCGTCACCCGTCACGGAAAGCTAGCAGCTGTCGTCGTGAGCGTCGCAGATCTTGAGGCGCTCGAGG
AATTCGAGATGGCTCAGGATGTAGCCGCCTACCGTGCCGCTCGCGCGGAAGACGATGGCGGACGGGTGAGCCTTGATGAA
CTACGACGCACATTGACACAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A7H8UAV4

References