Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 540212..540732 Replicon chromosome
Accession NZ_CP056080
Organism Rothia nasimurium strain E1706032

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag HWU94_RS02625 Protein ID WP_185174195.1
Coordinates 540212..540469 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag HWU94_RS02630 Protein ID WP_185174196.1
Coordinates 540478..540732 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HWU94_RS02590 535458..536537 + 1080 WP_185174188.1 hypothetical protein -
HWU94_RS02595 536529..536963 - 435 WP_185174189.1 PLD nuclease N-terminal domain-containing protein -
HWU94_RS02600 537081..537365 + 285 WP_185174190.1 DUF4229 domain-containing protein -
HWU94_RS02605 537362..538279 - 918 WP_185174191.1 1,4-dihydroxy-2-naphthoate polyprenyltransferase -
HWU94_RS02610 538370..539635 - 1266 WP_185174192.1 AMP-binding protein -
HWU94_RS02615 539743..539919 + 177 WP_185174193.1 hypothetical protein -
HWU94_RS02620 539922..540149 + 228 WP_185174194.1 hypothetical protein -
HWU94_RS02625 540212..540469 - 258 WP_185174195.1 Txe/YoeB family addiction module toxin Toxin
HWU94_RS02630 540478..540732 - 255 WP_185174196.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
HWU94_RS02635 540952..543840 + 2889 WP_185174732.1 class I SAM-dependent DNA methyltransferase -
HWU94_RS02640 543850..544002 + 153 WP_185174197.1 AAA family ATPase -
HWU94_RS02645 543997..544770 - 774 WP_185173408.1 transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(3-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10284.69 Da        Isoelectric Point: 10.2335

>T162602 WP_185174195.1 NZ_CP056080:c540469-540212 [Rothia nasimurium]
VELIWSSQAWEDYLWWQRQDRKVLKRINTLLKDIQRNGNEGIGKPEALRNNLSGYWSRRITEEHRLVYKIVGNSVRIAAV
RYHYE

Download         Length: 258 bp

>T162602 NZ_CP071872:c6835844-6835497 [Streptomyces formicae]
ATGAGACGTGGTGACATCTACATGGTTGACCTGGAACCGGCCCGTGGGAGCGAGGCCAACAAGGTCAGGCCGGCAGTGAT
CGTGTCGAACGACGGCGCCAACCAGTCGGTCGAGCGGAACGACAGAGGCGTGGTCACCGTGGCGCCACTGACGTCGAACA
CAACCCGCGTCCTCACCTTCCAGGTCCTGCTTCCTGCTGACGAAAGCCGTCTGCCCAAGGACTCCAAGGTCCAGTGCGAG
CAGGTGCGAGCCGTCGCACCGGAGCGCATCCTGCAGAGGGTCGGCTCTGTCCCGCGCCAGCGCATGGCCGAGATCGACAC
GGCGCTCCGGCGTCACCTGGCTCTGTAG

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9162.31 Da        Isoelectric Point: 4.1712

>AT162602 WP_185174196.1 NZ_CP056080:c540732-540478 [Rothia nasimurium]
MKTMTYTESRANYAQVLDIAVEDLEEVVITRAGREPAVILSLAEYESLKETAHLLRSPANARKLLDAIDELEAGGGSSQA
LLED

Download         Length: 255 bp

>AT162602 NZ_CP071872:c6836061-6835831 [Streptomyces formicae]
GTGAAGATCAGTGTGAGCCTGCCGCAGGAGGATGTCGCCTTCGTCGACGAGTACGTGACGAGAACCGAGGCCGAGTCCCG
GTCCGCCGTGATACACGCCGCGATCGAGCTTCTGCGCGCCGCGCAGCTGGAGGCGGAGTACACGGAGGCTTTCGCGGAGT
GGGACGCGAGCGAGGACGCTGCTCTGTGGGATCGGACGAGCGGGGACGGGATCACCGATGAGACGTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References