Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | I | Classification (family/domain) | hok-sok/- |
Location | 92828..93097 | Replicon | plasmid pMS1170_2 |
Accession | NZ_CP056079 | ||
Organism | Escherichia coli strain MS1170 |
Toxin (Protein)
Gene name | hok | Uniprot ID | P11895 |
Locus tag | HED12_RS23605 | Protein ID | WP_001312861.1 |
Coordinates | 92939..93097 (+) | Length | 53 a.a. |
Antitoxin (RNA)
Gene name | sok | ||
Locus tag | - | ||
Coordinates | 92828..92893 (+) |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
HED12_RS23570 | 87885..88151 | + | 267 | WP_072254135.1 | hypothetical protein | - |
HED12_RS23575 | 88621..89148 | + | 528 | WP_000290793.1 | single-stranded DNA-binding protein | - |
HED12_RS23580 | 89204..89437 | + | 234 | WP_000006004.1 | DUF905 domain-containing protein | - |
HED12_RS23585 | 89496..91454 | + | 1959 | WP_001145469.1 | ParB/RepB/Spo0J family partition protein | - |
HED12_RS23590 | 91509..91943 | + | 435 | WP_137433372.1 | conjugation system SOS inhibitor PsiB | - |
HED12_RS23595 | 91940..92659 | + | 720 | WP_001610270.1 | plasmid SOS inhibition protein A | - |
HED12_RS23600 | 92671..92859 | - | 189 | WP_001299721.1 | hypothetical protein | - |
- | 92671..92895 | + | 225 | NuclAT_0 | - | - |
- | 92671..92895 | + | 225 | NuclAT_0 | - | - |
- | 92671..92895 | + | 225 | NuclAT_0 | - | - |
- | 92671..92895 | + | 225 | NuclAT_0 | - | - |
- | 92828..92893 | + | 66 | - | - | Antitoxin |
HED12_RS23605 | 92939..93097 | + | 159 | WP_001312861.1 | type I toxin-antitoxin system Hok family toxin | Toxin |
HED12_RS23610 | 93788..93994 | + | 207 | WP_000547939.1 | hypothetical protein | - |
HED12_RS23615 | 94019..94306 | + | 288 | WP_000107537.1 | hypothetical protein | - |
HED12_RS23620 | 94426..95247 | + | 822 | WP_001234469.1 | DUF945 domain-containing protein | - |
HED12_RS23625 | 95544..96146 | - | 603 | WP_000243709.1 | transglycosylase SLT domain-containing protein | - |
HED12_RS23630 | 96467..96850 | + | 384 | WP_001151524.1 | relaxosome protein TraM | - |
HED12_RS23635 | 97037..97726 | + | 690 | WP_000283385.1 | conjugal transfer transcriptional regulator TraJ | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Conjugative plasmid | sitABCD | iroN / iroE / iroD / iroC / iroB | 1..134406 | 134406 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 53 a.a. Molecular weight: 6082.32 Da Isoelectric Point: 9.2584
>T162599 WP_001312861.1 NZ_CP056079:92939-93097 [Escherichia coli]
MKLPRSSLVWCVLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK
MKLPRSSLVWCVLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK
Download Length: 159 bp
>T162599 NZ_CP071871:1032303-1033064 [Streptococcus pneumoniae]
ATGGAAATCCAAGATTATACTGATAGTGAATTCAAACATGCTTTAGCAAGGAATCTTCGTTCACTGACAAGAGGAAAAAA
GTCCAGTAAACAACCTATAGCGATTTTGCTTGGAGGTCAAAGTGGTGCCGGTAAGACTACAATTCATCGTATTAAACAGA
AAGAATTTCAAGGAAATATTGTTATCATAGATGGTGATAGTTTTCGTTCTCAGCATCCACACTATTTAGAACTGCAGCAA
GAATATGGCAAAGACAGTGTAGAATATACCAAAGATTTTGCAGGAAAAATGGTAGAGTCTTTAGTAACAAAATTGAGTAG
TTTGAGATACAATCTTTTGATAGAGGGAACTTTACGAACAGTTGATGTTCCAAAGAAAACGGCACAACTCTTGAAAAATA
AGGGATATGAAGTACAATTAGCCTTGATTGCGACAAAGCCTAAGCTGTCCTATCTGAGCACTCTTATTCGATACGAAGAA
CTGTACGCTATCAATCCAAATCAAGCACGCGCAACACCAAAAGAACATCATGATTTCATTGTAAATCATCTAGTTGATAA
TACACGACAATTGGAAGAACTAGCTATTTTTGAAAGAATTCAAATTTACCAACGAGATAGAAGTTGTGTATATGATTCAA
AAGAAAATACAACTTCAGCAGCAGATGTTCTTCATGAGTTATTGTTTGGAGAGTGGAGTCAGGTAGAAAAGGAGATGTTG
AGGGTAGGGGAAAAGAGACTTAATGAATTACTTGAAAAATAA
ATGGAAATCCAAGATTATACTGATAGTGAATTCAAACATGCTTTAGCAAGGAATCTTCGTTCACTGACAAGAGGAAAAAA
GTCCAGTAAACAACCTATAGCGATTTTGCTTGGAGGTCAAAGTGGTGCCGGTAAGACTACAATTCATCGTATTAAACAGA
AAGAATTTCAAGGAAATATTGTTATCATAGATGGTGATAGTTTTCGTTCTCAGCATCCACACTATTTAGAACTGCAGCAA
GAATATGGCAAAGACAGTGTAGAATATACCAAAGATTTTGCAGGAAAAATGGTAGAGTCTTTAGTAACAAAATTGAGTAG
TTTGAGATACAATCTTTTGATAGAGGGAACTTTACGAACAGTTGATGTTCCAAAGAAAACGGCACAACTCTTGAAAAATA
AGGGATATGAAGTACAATTAGCCTTGATTGCGACAAAGCCTAAGCTGTCCTATCTGAGCACTCTTATTCGATACGAAGAA
CTGTACGCTATCAATCCAAATCAAGCACGCGCAACACCAAAAGAACATCATGATTTCATTGTAAATCATCTAGTTGATAA
TACACGACAATTGGAAGAACTAGCTATTTTTGAAAGAATTCAAATTTACCAACGAGATAGAAGTTGTGTATATGATTCAA
AAGAAAATACAACTTCAGCAGCAGATGTTCTTCATGAGTTATTGTTTGGAGAGTGGAGTCAGGTAGAAAAGGAGATGTTG
AGGGTAGGGGAAAAGAGACTTAATGAATTACTTGAAAAATAA
Antitoxin
Download Length: 66 bp
>AT162599 NZ_CP056079:92828-92893 [Escherichia coli]
AGAAGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCAC
AGAAGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCAC
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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