Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type I Classification (family/domain) hok-sok/-
Location 92828..93097 Replicon plasmid pMS1170_2
Accession NZ_CP056079
Organism Escherichia coli strain MS1170

Toxin (Protein)


Gene name hok Uniprot ID P11895
Locus tag HED12_RS23605 Protein ID WP_001312861.1
Coordinates 92939..93097 (+) Length 53 a.a.

Antitoxin (RNA)


Gene name sok
Locus tag -
Coordinates 92828..92893 (+)

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HED12_RS23570 87885..88151 + 267 WP_072254135.1 hypothetical protein -
HED12_RS23575 88621..89148 + 528 WP_000290793.1 single-stranded DNA-binding protein -
HED12_RS23580 89204..89437 + 234 WP_000006004.1 DUF905 domain-containing protein -
HED12_RS23585 89496..91454 + 1959 WP_001145469.1 ParB/RepB/Spo0J family partition protein -
HED12_RS23590 91509..91943 + 435 WP_137433372.1 conjugation system SOS inhibitor PsiB -
HED12_RS23595 91940..92659 + 720 WP_001610270.1 plasmid SOS inhibition protein A -
HED12_RS23600 92671..92859 - 189 WP_001299721.1 hypothetical protein -
- 92671..92895 + 225 NuclAT_0 - -
- 92671..92895 + 225 NuclAT_0 - -
- 92671..92895 + 225 NuclAT_0 - -
- 92671..92895 + 225 NuclAT_0 - -
- 92828..92893 + 66 - - Antitoxin
HED12_RS23605 92939..93097 + 159 WP_001312861.1 type I toxin-antitoxin system Hok family toxin Toxin
HED12_RS23610 93788..93994 + 207 WP_000547939.1 hypothetical protein -
HED12_RS23615 94019..94306 + 288 WP_000107537.1 hypothetical protein -
HED12_RS23620 94426..95247 + 822 WP_001234469.1 DUF945 domain-containing protein -
HED12_RS23625 95544..96146 - 603 WP_000243709.1 transglycosylase SLT domain-containing protein -
HED12_RS23630 96467..96850 + 384 WP_001151524.1 relaxosome protein TraM -
HED12_RS23635 97037..97726 + 690 WP_000283385.1 conjugal transfer transcriptional regulator TraJ -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid sitABCD iroN / iroE / iroD / iroC / iroB 1..134406 134406


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(8-48)


Sequences


Toxin        


Download         Length: 53 a.a.        Molecular weight: 6082.32 Da        Isoelectric Point: 9.2584

>T162599 WP_001312861.1 NZ_CP056079:92939-93097 [Escherichia coli]
MKLPRSSLVWCVLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK

Download         Length: 159 bp

>T162599 NZ_CP071871:1032303-1033064 [Streptococcus pneumoniae]
ATGGAAATCCAAGATTATACTGATAGTGAATTCAAACATGCTTTAGCAAGGAATCTTCGTTCACTGACAAGAGGAAAAAA
GTCCAGTAAACAACCTATAGCGATTTTGCTTGGAGGTCAAAGTGGTGCCGGTAAGACTACAATTCATCGTATTAAACAGA
AAGAATTTCAAGGAAATATTGTTATCATAGATGGTGATAGTTTTCGTTCTCAGCATCCACACTATTTAGAACTGCAGCAA
GAATATGGCAAAGACAGTGTAGAATATACCAAAGATTTTGCAGGAAAAATGGTAGAGTCTTTAGTAACAAAATTGAGTAG
TTTGAGATACAATCTTTTGATAGAGGGAACTTTACGAACAGTTGATGTTCCAAAGAAAACGGCACAACTCTTGAAAAATA
AGGGATATGAAGTACAATTAGCCTTGATTGCGACAAAGCCTAAGCTGTCCTATCTGAGCACTCTTATTCGATACGAAGAA
CTGTACGCTATCAATCCAAATCAAGCACGCGCAACACCAAAAGAACATCATGATTTCATTGTAAATCATCTAGTTGATAA
TACACGACAATTGGAAGAACTAGCTATTTTTGAAAGAATTCAAATTTACCAACGAGATAGAAGTTGTGTATATGATTCAA
AAGAAAATACAACTTCAGCAGCAGATGTTCTTCATGAGTTATTGTTTGGAGAGTGGAGTCAGGTAGAAAAGGAGATGTTG
AGGGTAGGGGAAAAGAGACTTAATGAATTACTTGAAAAATAA

Antitoxin


Download         Length: 66 bp

>AT162599 NZ_CP056079:92828-92893 [Escherichia coli]
AGAAGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCAC

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB P11895


Antitoxin

Download structure file

References