Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 1859807..1860409 Replicon chromosome
Accession NZ_CP056077
Organism Escherichia coli strain MS1170

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HED12_RS09465 Protein ID WP_202791745.1
Coordinates 1860098..1860409 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HED12_RS09460 Protein ID WP_000356397.1
Coordinates 1859807..1860097 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HED12_RS09435 1855880..1856782 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
HED12_RS09440 1856779..1857414 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
HED12_RS09445 1857411..1858340 + 930 WP_000027720.1 formate dehydrogenase accessory protein FdhE -
HED12_RS09450 1858556..1858774 - 219 WP_001314326.1 ribbon-helix-helix domain-containing protein -
HED12_RS09455 1859170..1859448 - 279 WP_001296612.1 hypothetical protein -
HED12_RS09460 1859807..1860097 - 291 WP_000356397.1 helix-turn-helix domain-containing protein Antitoxin
HED12_RS09465 1860098..1860409 - 312 WP_202791745.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HED12_RS09470 1860638..1861546 + 909 WP_001331553.1 alpha/beta hydrolase -
HED12_RS09475 1861610..1862551 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
HED12_RS09480 1862596..1863033 - 438 WP_000560978.1 D-tyrosyl-tRNA(Tyr) deacylase -
HED12_RS09485 1863030..1863902 - 873 WP_000920762.1 virulence factor BrkB family protein -
HED12_RS09490 1863896..1864495 - 600 WP_001314324.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12204.18 Da        Isoelectric Point: 9.4178

>T162580 WP_202791745.1 NZ_CP056077:c1860409-1860098 [Escherichia coli]
MLFIETEIFTEDVQKLLNDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPEEKAMLRLLNTRW

Download         Length: 312 bp

>T162580 NZ_CP056077:c1860409-1860098 [Escherichia coli]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGAACGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTCTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCGAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT162580 WP_000356397.1 NZ_CP056077:c1860097-1859807 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp

>AT162580 NZ_CP056077:c1860097-1859807 [Escherichia coli]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACAGCCTTC
ACGTACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGATC
TTATTTCCGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACCGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAAGCACTTAACCGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References