Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 1231561..1231819 Replicon chromosome
Accession NZ_CP056077
Organism Escherichia coli strain MS1170

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag HED12_RS06620 Protein ID WP_000809168.1
Coordinates 1231667..1231819 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 1231561..1231618 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HED12_RS06605 1227390..1228649 - 1260 WP_000494928.1 hypothetical protein -
HED12_RS06610 1228778..1230271 - 1494 WP_001443162.1 sulfatase-like hydrolase/transferase -
HED12_RS06615 1230291..1231052 - 762 WP_001274832.1 hypothetical protein -
- 1231561..1231618 - 58 - - Antitoxin
HED12_RS06620 1231667..1231819 + 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
HED12_RS06625 1231924..1233054 - 1131 WP_001118464.1 molecular chaperone DnaJ -
HED12_RS06630 1233143..1235059 - 1917 WP_000516135.1 molecular chaperone DnaK -
HED12_RS06635 1235432..1235836 + 405 WP_000843687.1 DUF2541 family protein -
HED12_RS06640 1235862..1236575 + 714 WP_001102393.1 acidic protein MsyB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T162576 WP_000809168.1 NZ_CP056077:1231667-1231819 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

>T162576 NZ_CP071861:678189-678476 [Enterobacter cloacae]
ATGCATAAATTAACACCCTACGATCCAGCCATCGCGTTGGTAGATGATGAGGAAATAGCCGTGTTTATGGCTGATGCATT
AGAAACCGGTGACTCAGCGTATATTGCTAAAGCTTTGGGCGTCATCGCGCGAGCGAAAGGGATGTCGACCATTTCACAGC
AAACTGGCCTGTCACGAGAACAACTGTACCGATCATTTAGTGATAAGGGGAACCCAACGCTTAAAACCACGCTGGCGGTC
ATGAAAGCATTGGGTCTTGGGCTCACAATCAAACCCGCCGGGGATTAA

Antitoxin


Download         Length: 58 bp

>AT162576 NZ_CP056077:c1231618-1231561 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References