Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 4390474..4390732 Replicon chromosome
Accession NZ_CP056036
Organism Escherichia coli strain EC31

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag HUW39_RS21135 Protein ID WP_000809168.1
Coordinates 4390580..4390732 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 4390474..4390531 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUW39_RS21120 4386866..4387825 + 960 WP_000871674.1 hypothetical protein -
HUW39_RS21125 4387863..4388762 - 900 WP_001300855.1 transcriptional activator NhaR -
HUW39_RS21130 4388828..4389994 - 1167 WP_000681360.1 Na+/H+ antiporter NhaA -
- 4390474..4390531 - 58 - - Antitoxin
HUW39_RS21135 4390580..4390732 + 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
HUW39_RS21140 4390836..4391966 - 1131 WP_001118464.1 molecular chaperone DnaJ -
HUW39_RS21145 4392055..4393971 - 1917 WP_000516135.1 molecular chaperone DnaK -
HUW39_RS21150 4394347..4394751 + 405 WP_000843584.1 DUF2541 family protein -
HUW39_RS21155 4394777..4395490 + 714 WP_001102367.1 acidic protein MsyB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T162535 WP_000809168.1 NZ_CP056036:4390580-4390732 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

>T162535 NZ_CP071844:80196-80465 [Vibrio sp. SCSIO 43009]
ATGAGTAGTAGTCAACGTTTACTGTCGTGGACTGATGACGCTTGGGATGACTACCTGTATTGGCAAACTCAAGACAAGAA
AACACTCAAGCGCATCAATAAACTCATCAATGATGTTAAACGCTCTCCATTTGAGGGCATCGGCAAACCAGAGCCGTTAA
AAGAGAACTTATCTGGTTTTTGGTCTCGCCGTATTGATGACACTAATAGGCTTGTTTACGCAGTCGATGATCAAGCGATA
ACGATAATTTCGTGTCGTTACCACTACTAA

Antitoxin


Download         Length: 58 bp

>AT162535 NZ_CP056036:c4390531-4390474 [Escherichia coli]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References