Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 807066..807759 Replicon chromosome
Accession NZ_CP056036
Organism Escherichia coli strain EC31

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag HUW39_RS03875 Protein ID WP_000415584.1
Coordinates 807066..807362 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag HUW39_RS03880 Protein ID WP_000650107.1
Coordinates 807364..807759 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUW39_RS03840 (802145) 802145..802459 - 315 WP_000958598.1 putative quinol monooxygenase -
HUW39_RS03845 (802490) 802490..803071 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
HUW39_RS03850 (803399) 803399..803731 + 333 WP_000917684.1 DUF2645 family protein -
HUW39_RS03855 (803777) 803777..805126 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
HUW39_RS03860 (805123) 805123..805782 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
HUW39_RS03865 (805934) 805934..806326 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
HUW39_RS03870 (806379) 806379..806861 + 483 WP_000183505.1 GyrI-like domain-containing protein -
HUW39_RS03875 (807066) 807066..807362 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
HUW39_RS03880 (807364) 807364..807759 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
HUW39_RS03885 (807892) 807892..809499 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
HUW39_RS03890 (809637) 809637..811895 + 2259 WP_001281841.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T162517 WP_000415584.1 NZ_CP056036:807066-807362 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T162517 NZ_CP071826:c1692619-1692203 [Burkholderia anthina]
GTGTTTTTGATTGATACGAACGTCATCAGCGAGATCAGAAAGGGCAAGCGAACCAACCGCGGCGTGCGCGCATTCTTCCG
GCAGGCCGAGGCCGACGCGAGCCCGCTTTACCTGTCGGTCGTCACGGTGGCCGAACTTCGGCGCGGCGTCGATCTGATCC
GTCATCGCGGCGATCACCAGCAGGCGTCGGCGCTCGAGGCCTGGATGGCGATGATCCTGTCCGGCTATGCGTCGAACATC
CTGCCGGTCGATATCGAGACCAGCCAGACGTGGGGCCATCTGCGCGTGCCCGATCCGACCCACGAACTCGACAAACTGAT
CGCGGCCACCGCGCTGATCAACGATCTCACGGTCGTCACGCGCAATGTCGACGATTTCGCCCGCACCGGCGTCCGGTTGT
TGAACCCTTTCGACTGA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT162517 WP_000650107.1 NZ_CP056036:807364-807759 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT162517 NZ_CP071826:c1692842-1692606 [Burkholderia anthina]
ATGGCAAATCTTCTGGTGCGTAACGTGGATGACAGTATCGTTCAGAGCCTGCGCGAGCAGGCTGCGGCCAACGGCAGGAG
CGCCGAGGCCGAACATCGGGCCATCCTGGCCGATGCGCTCGGCCGGCCGAAGCGACGGACATTCGCGCAGGTGCTGATGA
GCATGCCGGACGTCGGCGAAGACGCGGATTTCCAACGTGTTCAGGATTCCGGCGAGGTCAGGCGTGTTTTTGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References