Detailed information of TA system TA162510

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 3191827..3192085
• Replicon: chromosome
• Accession: NZ_CP056034
• Organism: Erwinia amylovora strain TS3128

Toxin (Protein)

• Gene name: hok
• Uniprot ID: D4I1C1
• Locus tag: HU055_RS14575
• Protein ID: WP_004160031.1
• Coordinates: 3191827..3191985 (-)
• Length: 53 a.a.

Antitoxin (RNA)

Gene name	sok
Locus tag	-
Coordinates	3192039..3192085 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HU055_RS14560	3187132..3188823	-	1692	WP_004160025.1	chloride channel protein	-
HU055_RS14565	3189236..3190216	+	981	WP_013035818.1	TerC family protein	-
HU055_RS14570	3190451..3191683	+	1233	WP_004160030.1	serine/threonine transporter SstT	-
HU055_RS14575	3191827..3191985	-	159	WP_004160031.1	type I toxin-antitoxin system Hok family toxin	Toxin
-	3192039..3192085	+	47	-	-	Antitoxin
HU055_RS14580	3192796..3193470	+	675	WP_004160034.1	DedA family protein	-
HU055_RS14585	3193467..3193859	+	393	WP_004160035.1	EnvZ/OmpR regulon moderator MzrA	-
HU055_RS14590	3194027..3194398	+	372	WP_004160036.1	DUF1090 domain-containing protein	-
HU055_RS14595	3194441..3194746	+	306	WP_004160037.1	DUF883 family protein	-
HU055_RS14600	3194748..3195140	+	393	WP_004160038.1	phage holin family protein	-
HU055_RS14605	3195140..3195421	+	282	WP_004160039.1	YqjK-like family protein	-
HU055_RS14610	3195631..3196023	+	393	WP_004160048.1	DoxX family protein	-
HU055_RS14615	3196496..3196639	+	144	WP_004160049.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (8-48)

Sequences

Toxin

Protein

• Length: 53 a.a.
• Molecular weight: 6038.32 Da
• Isoelectric Point: 8.4901

>T162510 WP_004160031.1 NZ_CP056034:c3191985-3191827 [Erwinia amylovora]
MKLPANCLIWCVLIVCVTLLIFTYLTRKSLCEIRYKDGYREVAAFMAYESGK

Nucleotide

• Length: 159 bp

>T162510 NZ_CP071825:c1868179-1867763 [Burkholderia anthina]
GTGACGACGCTCTATATGCTCGATACGAACATCTGCTCGTTCATCATGCGCGAGCGGCCGCCCGTGGTGTTGTCCCGGCT
GCAGTCGTGCGTCAATGCGCAGCACCGGATCGTTGTGTCGGCGATCACCTATGCCGAAATGCGATTCGGCGCTGTGGGCA
AGAAGGCGTCGCCAAAGCATGCGGCACTCGTGACGGCCTTCGTCGCACGGCTGGACGGCGTGCTGTCGTGGGATACGGCC
GCAGTTGATGCAACGACAGCGATTCGAGCCGATCTCGCGGCCCGCGGCACGCCGATCGGCGCAAACGATGCGTCGATCGC
CGGCCATGCCATTGCCGCCGGCGCGGTGCTCGTGACGAATAACGGTCGTGAATTCAGTCGCGTCGCGGGGTTGTCCGTCG
AAGACTGGGCAGCTTGA

Antitoxin

Nucleotide

• Length: 47 bp

>AT162510 NZ_CP056034:3192039-3192085 [Erwinia amylovora]
GCATGCAGATGGCCTCGTGGATTAATGAAAATTAACTACGGGGCTTT

Structures

Toxin

• AlphaFold DB: A0A831A7I1

Antitoxin