Detailed information of TA system TA162502

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-RelB
• Location: 5450246..5450757
• Replicon: chromosome
• Accession: NZ_CP056032
• Organism: Spirosoma sp. KUDC1026

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: HU175_RS22980
• Protein ID: WP_176568801.1
• Coordinates: 5450246..5450500 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: HU175_RS22985
• Protein ID: WP_176568802.1
• Coordinates: 5450503..5450757 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HU175_RS22960	5446847..5447605	+	759	WP_176568797.1	hypothetical protein	-
HU175_RS22965	5447661..5448623	-	963	WP_176568798.1	alpha-E domain-containing protein	-
HU175_RS22970	5448771..5449535	+	765	WP_176568799.1	NIPSNAP family protein	-
HU175_RS22975	5449595..5450200	-	606	WP_176568800.1	hypothetical protein	-
HU175_RS22980	5450246..5450500	-	255	WP_176568801.1	Txe/YoeB family addiction module toxin	Toxin
HU175_RS22985	5450503..5450757	-	255	WP_176568802.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
HU175_RS22990	5450875..5451198	+	324	WP_176568803.1	nucleotidyltransferase domain-containing protein	-
HU175_RS22995	5451195..5451590	+	396	WP_176568804.1	HEPN domain-containing protein	-
HU175_RS23000	5451596..5453446	-	1851	WP_176568805.1	ABC transporter ATP-binding protein/permease	-
HU175_RS23005	5453574..5454953	+	1380	WP_176568806.1	thioredoxin family protein	-
HU175_RS23010	5455141..5455344	-	204	Protein_4551	hypothetical protein	-
HU175_RS23015	5455349..5455735	-	387	WP_176568807.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (1-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-70)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10313.75 Da
• Isoelectric Point: 9.0719

>T162502 WP_176568801.1 NZ_CP056032:c5450500-5450246 [Spirosoma sp. KUDC1026]
MNLSWDKNAREDYVYWQQTDKSVLRRINELVKECMRTPFDGKGKPEPLKENLSGFWSRRITDEHRLVYRVEADRLHIIQC
RFHY

Nucleotide

• Length: 255 bp

>T162502 NZ_CP071820:36183-36653 [Klebsiella pneumoniae subsp. pneumoniae]
GTGATCCTCTACAGGCTGACGAAAACAAAGTATCTTTCTACGGCCTGGACCGGATATGGTGCGAAAGAGGCTGGTGGGCG
CTGGAATAGCGTGGGGGTGTCAATGGTATATGTCTCCGAAACGGCTTCACTAACGATGCTGGAGACGCTGGTACACCTGC
ATGCGGCACAGATAATGGACTCTTTCACGCTACTGAGTATCGATGTGCCTGATGAACTGATCCAAAGCGCAAACATGGAT
GAATTACCGGACAACTGGGCTGATGAGGATGCGCCTCAGGAACTGGCTGATTACGGAGATGCCTGGTCATTTACCAGGAG
CTCGGTTGCACTGCGTGTTCCCTCAGCCTTATCGCCGGTAGAGTTCAACTATCTGTTAAATCCTGAGCACCCTGAGTTTT
ACGGGATCGTGCAGAAGGCTCAACAGATACCGTTCCGGTTTGATAGTCGTCTTAAACCTGACAGGAAGTGA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9896.01 Da
• Isoelectric Point: 4.6652

>AT162502 WP_176568802.1 NZ_CP056032:c5450757-5450503 [Spirosoma sp. KUDC1026]
MQVVNYSEFRRSMKAKLDQVSDDNDMIVINRSENKNVVLISLREYNSLKETLHLLSSENNRNRLMSAVERANWGEQEDHD
LIDE

Nucleotide

• Length: 255 bp

>AT162502 NZ_CP071820:35743-36186 [Klebsiella pneumoniae subsp. pneumoniae]
ATGAAAACTTTTAGTTTGTCCTCAACTCCAGCCAGACCACAGCGCCTCTGGCAGGTTGCCGGGTTAAATAATGCTGATGG
TGTAGCGCTCCTGGGCCAAATCAATGAAGGCCTGGACGGGAAGGTGGCGAACCGGATCACTGACTGGGCCAGAATAACCC
AGAATGACCTGAGAAAAATGTCCGGTATCCCGTCGACCACGTTTAGCCGCAGTGTGAAGGCACGTTTTAACCCGGAACAA
AGTGAACGTCTGGTTCGGATTATCCGCGTCATTGATCGGGCGGTAGATTTGTTTGAAGGCGACAGGGAAGCCGCACAGAA
GTGGTTGAACGAACCTAACCGGGCATTGAGCTGGAAAGTGCCAGCAGACCTGATGGCATCCGAGACAGGAGCGTATGAGG
TCATTAAGCTGATTACGCGTCTGGAGCATGGGGTGTACTCGTGA