Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 4568734..4569338 Replicon chromosome
Accession NZ_CP056030
Organism Pseudomonas eucalypticola strain NP-1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HWQ56_RS20245 Protein ID WP_176571621.1
Coordinates 4569018..4569338 (-) Length 107 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HWQ56_RS20240 Protein ID WP_158153970.1
Coordinates 4568734..4569021 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HWQ56_RS20225 4564690..4565973 - 1284 WP_158153967.1 ATP-dependent Clp protease ATP-binding subunit ClpX -
HWQ56_RS20230 4566081..4566722 - 642 WP_158153968.1 ATP-dependent Clp endopeptidase proteolytic subunit ClpP -
HWQ56_RS20235 4566815..4568125 - 1311 WP_176571620.1 trigger factor -
HWQ56_RS20240 4568734..4569021 - 288 WP_158153970.1 helix-turn-helix domain-containing protein Antitoxin
HWQ56_RS20245 4569018..4569338 - 321 WP_176571621.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HWQ56_RS20270 4570230..4571084 + 855 WP_176571622.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD -
HWQ56_RS20275 4571171..4572913 - 1743 WP_176571623.1 ABC transporter substrate-binding protein -
HWQ56_RS20280 4572961..4573233 - 273 WP_158158759.1 DUF2160 domain-containing protein -
HWQ56_RS20285 4573245..4574045 - 801 WP_158158757.1 carbohydrate ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(43-99)

Antitoxin

Cro/C1-type helix-turn-helix domain

(35-86)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 11677.66 Da        Isoelectric Point: 10.3124

>T162500 WP_176571621.1 NZ_CP056030:c4569338-4569018 [Pseudomonas eucalypticola]
MIFIETPVFTRRAIELLDHDGYLGLQLQLVSDPCAGALIEGTGGVRKIRVAANGHGKRGGARVIYYHFVGASRIALLMIY
AKGEKADLTAQERKQLKLAIERWGRA

Download         Length: 321 bp

>T162500 NZ_CP071819:c4890442-4889525 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGATATACAGGCGCCTTATTATCGGCAGGTTGCTCTGCTAATGCAGGTTTTACCCTATGTTGCTGTCGAACGGGAATT
TGCGCTGAAAGGTGGCACTGCCATCAATCTCTTTATCCGCGATTTCCCTCGATTATCGGTGGATATCGACCTCGCCTGGG
TGCCCCTGGAAAGCAGAGCCATCGCTTTACCTCATATACGGGATGCGCTTGCACGTATTGCCGCCAATCTGCAACAACAG
GCAGGTATGAGCGCTGTATTACAAGCTAATCGTTCAGATGAGATGCGTGTCATTGTTACTACCGATAGCGCGCAAATAAA
GATAGAGGTTTCACCGGTCGCCCGGGGAACATTATATCCACCACAGGAGCGAGAAGTGGTGGGGGCGGTAGAGGACGTTT
TTGGCTATGCCAGCCTTCCAGTGGTTTCGTTGCCTGACCTCTACGGTGGAAAATTATGCGCGGCGCTGGATCGCCAGCAT
CCCAGAGATTTTTATGACGTGAAATTACTTCTTGATGCGCAGGAGCTTGACCGTCCCATTTTCAATGGGTTTATCGCGTA
TTTACTGAGCCATAATCGGCCTCTGGCTGAAGTGCTGAATCCTCGCTGGAAAGATATTGCTGAACCTTTTTACCGTGAAT
TCAGCGGGATGACATTTGAGACGATAGCCCTGGAGGAACTGACAGCAGTCCCCAACAGGATGATTGCTGCGTTAAAATCC
TGTTTCACACAACAGGATGTCGATTTTTTACTGTCATTTAAACGAGGCGAACCAGACTGGCGTTTAGCGCCGGAAATGCG
TATTCAGGATTTGCCTGCCGTGCAGTGGAAATTGCGCAATATTCATCAGATGCCAGCGATAAAACGCGCTGAGTCATTAG
ATAAACTGGAAAAGGTGCTGGCCGAGTGGCGCAGTTAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10655.28 Da        Isoelectric Point: 7.3210

>AT162500 WP_158153970.1 NZ_CP056030:c4569021-4568734 [Pseudomonas eucalypticola]
MSTFFEELMESVGQMDEILRGEREPSREFHVDALQVKAIRKATGLSQVKFAAMIDVQLGTLRNWEQGRRQPTGPAKALLK
AIHNDPVHVLNALSV

Download         Length: 288 bp

>AT162500 NZ_CP071819:c4891206-4890448 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGCAACAAAATTAAACTGGCTGCTGCAAAACAGCGCTCCCGGAGATGTGATCCTTCAGTCCTGGTTAAGCCAGCATGC
CATCTCTCCCTCTCTGGCCTTTAAATACGCGCAAAGTGGCTGGTTAAAAAAAAGAGGCAACGGCGTATATGCGCGTGCGG
GACGTGAGCCGGAGTGGAACGATGCATTAGCATGTTTGCAAAATCAGCTTGCCGCTCCGGTGTATGTTGCGGGGCTCAGT
AGCTTAGTCTGGCAGGGCCGTTCACACTATCTACAGCTAAAACAAAACCAGTGCTGGCTTAGTGTGGAAAATAAAGCGCT
GCTGCCGAAATGGTTCAGGGAATTCCCGGGTGTGGAGTGGATAGTCATATCGGGGAAAAAACTGCCGGTGCTGGATGATA
GATACCGTGTAACGCTTGATATAAAAGGGAAAAAACTCATCGGCAGTGCGCCAGAACTGGCTGCTTACGAGTTGCTGAGC
GCGGTGCCGGGGACCCTCTCATTTAACCACGCTGCAGAGCTTTTCCAGGGGCTGGTTAATCTTAATCCTCGTAAAGTAGA
GTATCTTCTTTCCGTCAGCCAGTCCGTGCAGGCCAAGCGTTTGTATCTCTTCTTCGCCAGTTTTTACGAGCATGGCTGGC
TCAAACGAATCGATAGCCAAAAAATCGATCTGGGAGCGGGCAAGCGGCAAATCGTGGAAAATGGAAAGTTCAATGCTCAA
TACCAAATCACAGTGCCTGAACGCTTTCAAAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References