Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 50..589 Replicon plasmid unnamed
Accession NZ_CP055885
Organism Enterobacter sp. RHBSTW-00975

Toxin (Protein)


Gene name yafQ Uniprot ID J2DZM3
Locus tag HV340_RS23980 Protein ID WP_004150484.1
Coordinates 314..589 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID A0A5H6MLU0
Locus tag HV340_RS23975 Protein ID WP_001570852.1
Coordinates 50..310 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV340_RS23975 50..310 + 261 WP_001570852.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HV340_RS23980 314..589 + 276 WP_004150484.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
HV340_RS23985 540..746 + 207 WP_162184628.1 hypothetical protein -
HV340_RS23990 758..1414 - 657 WP_060437122.1 hypothetical protein -
HV340_RS23995 1746..2273 + 528 WP_048242344.1 ankyrin repeat domain-containing protein -
HV340_RS24000 2284..2493 + 210 WP_048242343.1 hypothetical protein -
HV340_RS24005 2490..2789 + 300 WP_048242342.1 hypothetical protein -
HV340_RS24010 2786..3079 + 294 WP_048242341.1 hypothetical protein -
HV340_RS24015 3215..3526 + 312 WP_048242340.1 hypothetical protein -
HV340_RS24020 3529..4086 + 558 WP_053071116.1 prepilin-type N-terminal cleavage/methylation domain-containing protein -
HV340_RS24025 4102..4641 + 540 WP_045307794.1 prepilin-type N-terminal cleavage/methylation domain-containing protein -
HV340_RS24030 4658..4852 + 195 WP_048242338.1 hypothetical protein -
HV340_RS24035 4905..5351 - 447 WP_045351267.1 H-NS histone family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..43121 43121


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-83)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10750.40 Da        Isoelectric Point: 9.6586

>T162496 WP_004150484.1 NZ_CP055885:314-589 [Enterobacter sp. RHBSTW-00975]
MTTRTIEYSGQFQKDVKKAQKRHKDMSKLKALMTLLINDALPLPQVYKDHPLQGNYKGYRDAHIEPDWLLIYKITDEVLR
FERTGTHSDLF

Download         Length: 276 bp

>T162496 NZ_CP071819:c2698235-2696913 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGAGGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCGCTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCAGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
CAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAATGAGTATCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCACCACCCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCGGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9239.63 Da        Isoelectric Point: 5.0336

>AT162496 WP_001570852.1 NZ_CP055885:50-310 [Enterobacter sp. RHBSTW-00975]
MAANAFVRARIDETLKNEAAVVLAGMGLTVSDLVRITLTKVAKEKALPFDMRVPNELTANTIANSEKGVDVHTAKDADDL
FNQLGI

Download         Length: 261 bp

>AT162496 NZ_CP071819:c2698501-2698235 [Klebsiella pneumoniae subsp. pneumoniae]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAATTACATGAAGCTGCTGCGCCAGCAGAACCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGACGCTGAACGCCAAAGCTGCTGAGACGGCGCCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB J2DZM3

Antitoxin

Source ID Structure
AlphaFold DB A0A5H6MLU0

References