Detailed information of TA system TA162478

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 4461411..4461669
• Replicon: chromosome
• Accession: NZ_CP055675
• Organism: Escherichia fergusonii strain RHB28-C13

Toxin (Protein)

• Gene name: hokA
• Uniprot ID: -
• Locus tag: HVY52_RS21605
• Protein ID: WP_181202950.1
• Coordinates: 4461411..4461563 (-)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokA
Locus tag	-
Coordinates	4461614..4461669 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HVY52_RS21580	4457275..4457985	-	711	WP_000190514.1	DUF3053 domain-containing protein	-
HVY52_RS21585	4458423..4459793	+	1371	WP_000184983.1	MFS transporter	-
HVY52_RS21590	4460043..4460333	+	291	WP_000455800.1	HTH-type transcriptional regulator	-
HVY52_RS21595	4460615..4460827	+	213	WP_000014594.1	RNA chaperone/antiterminator CspA	-
HVY52_RS21600	4460881..4461252	-	372	WP_001037803.1	membrane protein insertion efficiency factor YidD	-
HVY52_RS21605	4461411..4461563	-	153	WP_181202950.1	type I toxin-antitoxin system toxin HokA	Toxin
-	4461614..4461669	+	56	-	-	Antitoxin
HVY52_RS21610	4461864..4462223	-	360	WP_141095883.1	hypothetical protein	-
HVY52_RS21615	4462292..4464361	-	2070	WP_001291786.1	glycine--tRNA ligase subunit beta	-
HVY52_RS21620	4464371..4465282	-	912	WP_181202951.1	glycine--tRNA ligase subunit alpha	-
HVY52_RS21625	4465378..4465677	-	300	WP_024256552.1	YsaB family lipoprotein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-46)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5926.17 Da
• Isoelectric Point: 6.9160

>T162478 WP_181202950.1 NZ_CP055675:c4461563-4461411 [Escherichia fergusonii]
MPQKYGLLSLIVICFTLLFFTWMIRDSLCELHIKQENYELAAFLACKLKE

Nucleotide

• Length: 153 bp

>T162478 NZ_CP071802:3050786-3051142 [Yersinia ruckeri]
ATGAAACCACGCCCCACAGCGCAGGGTGCATTGCCCGTGCCTGTTATTTATCAACAACTGCTCGCTTTTCTGCTGGAGCA
CCACTATGGCCTGAGCCTCAACGATACGCCCTATCACGATGAACAGGCGATTGCACAACAGATAGAACAAGGGATTTCAG
TCGGTGACACCATTAATGCCCTGGTTGAGAAATATGCCTTAGTGCAAATTGGTCGTAACGGGTTCAGCGCACTGGCGCAA
GACCCGATGTTAAGCAAAGGCGATATCGTGCGGGCTCGCCAGGCTTCGGGCTTGTGGCGTGCTCATTTTCCACCCACGTT
GCTGTACCCAACCGAGTCCCTCAATCCTATTCCATAG

Antitoxin

Nucleotide

• Length: 56 bp

>AT162478 NZ_CP055675:4461614-4461669 [Escherichia fergusonii]
GTTGAAGCATAGAGGCAGCCTCACTTTGATTTATAGTCAGGTGGGGCTTTTCTCTG

Structures

Antitoxin