Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2330314..2330876 Replicon chromosome
Accession NZ_CP055675
Organism Escherichia fergusonii strain RHB28-C13

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HVY52_RS11330 Protein ID WP_104919749.1
Coordinates 2330598..2330876 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID S1PAQ1
Locus tag HVY52_RS11325 Protein ID WP_000781370.1
Coordinates 2330314..2330598 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVY52_RS11310 2325673..2328720 + 3048 WP_015953395.1 formate dehydrogenase-N subunit alpha -
HVY52_RS11315 2328733..2329617 + 885 WP_001240580.1 formate dehydrogenase N subunit beta -
HVY52_RS11320 2329610..2330263 + 654 WP_000045648.1 formate dehydrogenase-N subunit gamma -
HVY52_RS11325 2330314..2330598 - 285 WP_000781370.1 HigA family addiction module antidote protein Antitoxin
HVY52_RS11330 2330598..2330876 - 279 WP_104919749.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HVY52_RS11335 2331062..2332072 - 1011 WP_000642407.1 alcohol dehydrogenase AdhP -
HVY52_RS11340 2332206..2333903 - 1698 WP_181203469.1 malate dehydrogenase -
HVY52_RS11345 2334060..2334197 - 138 WP_000841554.1 stationary-phase-induced ribosome-associated protein -
HVY52_RS11350 2334299..2334514 - 216 WP_000495766.1 biofilm-dependent modulation protein -
HVY52_RS11355 2334856..2335287 + 432 WP_000152305.1 peroxiredoxin OsmC -
HVY52_RS11360 2335348..2335488 + 141 WP_181203495.1 omptin family outer membrane protease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-88)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10521.10 Da        Isoelectric Point: 7.3562

>T162469 WP_104919749.1 NZ_CP055675:c2330876-2330598 [Escherichia fergusonii]
MIMNFRHKGLRDLFLLGKTSGVIPTQVKRLRHRLAVIDAASCLADLDMPGYRLHPLSGDRDGIWAISVSGNWRITFEFVN
GDAYILDYEDYH

Download         Length: 279 bp

>T162469 NZ_CP071797:5540788-5541042 [Pseudomonas fluorescens]
ATGGACACTATCAACTACACCACAGCTCGTGCGCACTTGGCTGAAACCATGGATCGCGTGAATGAAGACTGCACCCCGCT
TCTGGTAACCCGCCAAAAAGGCGAGCCTGTAGTAATGATGTCTCTGGCCGAATACAACGCGCTGGAAGAAACGGCTTATC
TGCTGCGCTCTCCGGCCAATGCCGAGCGCTTGATCAAATCGATTGGCGAAATGCGCGCTGGAAAAGCCAAAGTCAGGCAA
CTGATTGAAGAATGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10401.08 Da        Isoelectric Point: 8.8567

>AT162469 WP_000781370.1 NZ_CP055675:c2330598-2330314 [Escherichia fergusonii]
MKMANHPRPGDIIQESLDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPQMWLNLQNAWSLAEAE
KTVDVSRLRRLVTQ

Download         Length: 285 bp

>AT162469 NZ_CP071797:5541039-5541293 [Pseudomonas fluorescens]
ATGAAAATCCAGTTCACGCCAACGGGCTGGGAAGACTACTTATGGTTTCAACAAAACGATAAGGCCGGTCTCAAACGAAT
CAATCTTTTGATCAAAGCGATCCAGCGCCAACCCTTTGAAGGCTTGGGTAAACCGGAGCCGCTCAAGCACAACATGAGCG
GCTTCTGGTCACGGCAGATAACTGCCGAGCATCGCCTGGTCTATGCAATCGTAGACGACGAAATCTGCGTCATAACTTGC
AGATTTCACTACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 2ICT
PDB 2ICP
AlphaFold DB A0A829CUG6

References