Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type I Classification (family/domain) hok-sok/-
Location 2054424..2054649 Replicon chromosome
Accession NZ_CP055675
Organism Escherichia fergusonii strain RHB28-C13

Toxin (Protein)


Gene name hokW Uniprot ID A0A8E4IMY5
Locus tag HVY52_RS09825 Protein ID WP_000813260.1
Coordinates 2054494..2054649 (+) Length 52 a.a.

Antitoxin (RNA)


Gene name sokW
Locus tag -
Coordinates 2054424..2054482 (-)

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVY52_RS09785 2049484..2049702 - 219 WP_001171946.1 hypothetical protein -
HVY52_RS09790 2049774..2050073 - 300 WP_042046576.1 hypothetical protein -
HVY52_RS09795 2050427..2050765 - 339 WP_001397087.1 peptidase S24-like family protein -
HVY52_RS09800 2051157..2051399 + 243 WP_000747951.1 hypothetical protein -
HVY52_RS09805 2051383..2051808 + 426 WP_000693883.1 Rha family transcriptional regulator -
HVY52_RS09810 2051880..2052950 + 1071 WP_023154928.1 phage replisome organizer protein -
HVY52_RS09815 2052991..2053416 + 426 WP_021546098.1 DUF977 family protein -
HVY52_RS09820 2053591..2054256 + 666 WP_000150294.1 epoxyqueuosine reductase QueH -
- 2054424..2054482 - 59 - - Antitoxin
HVY52_RS09825 2054494..2054649 + 156 WP_000813260.1 type I toxin-antitoxin system toxin HokD Toxin
HVY52_RS09830 2054793..2055185 + 393 WP_000737636.1 hypothetical protein -
HVY52_RS09835 2055482..2055760 + 279 WP_024175747.1 hypothetical protein -
HVY52_RS09840 2055762..2056811 + 1050 WP_048949148.1 DUF968 domain-containing protein -
HVY52_RS09845 2056824..2057183 + 360 WP_089585352.1 RusA family crossover junction endodeoxyribonuclease -
HVY52_RS09850 2057180..2057869 + 690 WP_181203391.1 antiterminator -
HVY52_RS09875 2058666..2058881 + 216 WP_000839572.1 class II holin family protein -
HVY52_RS09880 2058886..2059236 + 351 WP_001545374.1 YdfR family protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2037393..2091190 53797


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(6-47)


Sequences


Toxin        


Download         Length: 52 a.a.        Molecular weight: 5766.92 Da        Isoelectric Point: 6.1531

>T162467 WP_000813260.1 NZ_CP055675:2054494-2054649 [Escherichia fergusonii]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVTVFTAYEPEE

Download         Length: 156 bp

>T162467 NZ_CP071797:c2505289-2505020 [Pseudomonas fluorescens]
ATGCAGGTTGAGTGGCAGCCCGAAGCTCGGGCTGAACTCCTGCACATTCTTGACTACATCAGTGACCGGAATTTCAAAGC
GGCTAACAAGCTTTCAAACGCTATCGAAGCCGCCACGGTTACCCTTACCAAACATCCACACCTCTATCGAGTGGGGCGAA
CTCCCGGCACTCGTGAGATGGTCGTACATCCCAACTACCTGCTCATTTACCAAGCGGTGGGCCGGATAAATATTCTGGGC
GTTGTGCACGCACGTCAGGAATATCCGTGA

Antitoxin


Download         Length: 59 bp

>AT162467 NZ_CP055675:c2054482-2054424 [Escherichia fergusonii]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTAGATTTGCCGTTCATAGATTGAGCCTCA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Download structure file

References