Detailed information of TA system TA162453

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 691139..691397
• Replicon: chromosome
• Accession: NZ_CP055675
• Organism: Escherichia fergusonii strain RHB28-C13

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: -
• Locus tag: HVY52_RS03385
• Protein ID: WP_000935262.1
• Coordinates: 691139..691348 (-)
• Length: 70 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	691340..691397 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HVY52_RS03365	686205..686792	+	588	WP_002431696.1	molybdopterin adenylyltransferase	-
HVY52_RS03370	686826..687392	-	567	WP_000528529.1	acetate uptake transporter	-
HVY52_RS03375	687900..689816	+	1917	WP_000516135.1	molecular chaperone DnaK	-
HVY52_RS03380	689905..691035	+	1131	WP_001118464.1	molecular chaperone DnaJ	-
HVY52_RS03385	691139..691348	-	210	WP_000935262.1	type I toxin-antitoxin system Hok family toxin	Toxin
-	691340..691397	+	58	-	-	Antitoxin
HVY52_RS03390	691832..692998	+	1167	WP_000681374.1	Na+/H+ antiporter NhaA	-
HVY52_RS03395	693066..693965	+	900	WP_000019049.1	transcriptional activator NhaR	-
HVY52_RS03400	694061..694324	-	264	WP_001274021.1	30S ribosomal protein S20	-
HVY52_RS03405	694427..694645	+	219	WP_181203115.1	DUF2575 domain-containing protein	-
HVY52_RS03410	694653..695594	+	942	WP_000767329.1	bifunctional riboflavin kinase/FAD synthetase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (25-66)

Sequences

Toxin

Protein

• Length: 70 a.a.
• Molecular weight: 7742.28 Da
• Isoelectric Point: 9.3680

>T162453 WP_000935262.1 NZ_CP055675:c691348-691139 [Escherichia fergusonii]
MLNTCRVPLTDRKVKEKRAMKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 210 bp

>T162453 NZ_CP071795:2247679-2247825 [Polaribacter batillariae]
ATGCGAATAAATTTTGCGAAAGGTTACAGAGTTTACTTCAAGGAAAAGGACGGAAAAGTAATTGTTCTTCTGATTGGCGG
AGATAAATCAACTCAACAAAAAGACATTGCAAAAGCGAAAGAAATTTGGAAAAAATTAAATAAATAG

Antitoxin

Nucleotide

• Length: 58 bp

>AT162453 NZ_CP055675:691340-691397 [Escherichia fergusonii]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Antitoxin