Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 3843116..3843362 Replicon chromosome
Accession NZ_CP055599
Organism Escherichia fergusonii strain RHB41-C23

Toxin (Protein)


Gene name hokX Uniprot ID S1PD89
Locus tag HV014_RS18600 Protein ID WP_000956458.1
Coordinates 3843210..3843362 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokX
Locus tag -
Coordinates 3843116..3843168 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV014_RS18585 3838624..3840423 + 1800 WP_181198774.1 NADPH-dependent assimilatory sulfite reductase flavoprotein subunit -
HV014_RS18590 3840423..3842135 + 1713 WP_046083135.1 assimilatory sulfite reductase (NADPH) hemoprotein subunit -
HV014_RS18595 3842209..3842943 + 735 WP_046083134.1 phosphoadenosine phosphosulfate reductase -
- 3843116..3843168 - 53 - - Antitoxin
HV014_RS18600 3843210..3843362 + 153 WP_000956458.1 type I toxin-antitoxin system Hok family toxin Toxin
HV014_RS18605 3843598..3846255 + 2658 WP_181198775.1 CRISPR-associated helicase Cas3' -
HV014_RS18610 3846721..3848283 + 1563 WP_104920139.1 type I-E CRISPR-associated protein Cse1/CasA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(5-46)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5558.77 Da        Isoelectric Point: 7.6757

>T162441 WP_000956458.1 NZ_CP055599:3843210-3843362 [Escherichia fergusonii]
MLTKYALVAIIVLCCTVLGFTLMVGDSLCELSIRERGMEFKAVLAYESKK

Download         Length: 153 bp

>T162441 NZ_CP071785:c334887-334633 [Marinobacter sp. CA1]
ATGAAACTCGTCTTCTCTGAGAACGCCTGGGAAGACTATCTGTACTGGCAAAAAACCGACAAAAAGATTCTTAACCGAAT
CAACAAGCTGATCAAGGAGACCAAGCGAGAGCCGTTCGAAGGTGTTGGCAAACCAGAGCCCCTCAAACACAGCCTCGCCG
GATACTGGTCTCGCCGGATCAACGAAGAACACCGAATAGTTTACAAAGTCACGGATGACGCTTTGCTTATCGCCCAGCTC
CGGTATAACTACTGA

Antitoxin


Download         Length: 53 bp

>AT162441 NZ_CP055599:c3843168-3843116 [Escherichia fergusonii]
TTAGGTTCGAACGCTGGCCTCAGGTTGATAGAAATATCGCCTGGGGCTTTTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TJ83

Antitoxin

Download structure file

References