Detailed information of TA system TA162432

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-ohsC/Ldr(toxin)
• Location: 2517653..2517872
• Replicon: chromosome
• Accession: NZ_CP055599
• Organism: Escherichia fergusonii strain RHB41-C23

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: A0A826RQE3
• Locus tag: HV014_RS12260
• Protein ID: WP_000170746.1
• Coordinates: 2517653..2517760 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	ohsC
Locus tag	-
Coordinates	2517809..2517872 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HV014_RS12235	2512889..2513656	-	768	WP_181198551.1	cellulose biosynthesis protein BcsQ	-
HV014_RS12240	2513668..2513856	-	189	WP_001063310.1	YhjR family protein	-
HV014_RS12245	2514143..2515702	+	1560	WP_001070267.1	cellulose biosynthesis protein BcsE	-
HV014_RS12250	2515699..2515890	+	192	WP_000981122.1	cellulose biosynthesis protein BcsF	-
HV014_RS12255	2515887..2517566	+	1680	WP_000192007.1	cellulose biosynthesis protein BcsG	-
HV014_RS12260	2517653..2517760	-	108	WP_000170746.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
-	2517809..2517872	+	64	NuclAT_13	-	Antitoxin
-	2517809..2517872	+	64	NuclAT_13	-	Antitoxin
-	2517809..2517872	+	64	NuclAT_13	-	Antitoxin
-	2517809..2517872	+	64	NuclAT_13	-	Antitoxin
-	2517809..2517872	+	64	NuclAT_14	-	Antitoxin
-	2517809..2517872	+	64	NuclAT_14	-	Antitoxin
-	2517809..2517872	+	64	NuclAT_14	-	Antitoxin
-	2517809..2517872	+	64	NuclAT_14	-	Antitoxin
-	2517809..2517872	+	64	NuclAT_15	-	Antitoxin
-	2517809..2517872	+	64	NuclAT_15	-	Antitoxin
-	2517809..2517872	+	64	NuclAT_15	-	Antitoxin
-	2517809..2517872	+	64	NuclAT_15	-	Antitoxin
-	2517809..2517872	+	64	NuclAT_16	-	Antitoxin
-	2517809..2517872	+	64	NuclAT_16	-	Antitoxin
-	2517809..2517872	+	64	NuclAT_16	-	Antitoxin
-	2517809..2517872	+	64	NuclAT_16	-	Antitoxin
-	2517809..2517874	+	66	NuclAT_10	-	-
-	2517809..2517874	+	66	NuclAT_10	-	-
-	2517809..2517874	+	66	NuclAT_10	-	-
-	2517809..2517874	+	66	NuclAT_10	-	-
-	2517809..2517874	+	66	NuclAT_11	-	-
-	2517809..2517874	+	66	NuclAT_11	-	-
-	2517809..2517874	+	66	NuclAT_11	-	-
-	2517809..2517874	+	66	NuclAT_11	-	-
HV014_RS12265	2518196..2519392	+	1197	WP_104920204.1	methionine gamma-lyase	-
HV014_RS12270	2519642..2520940	+	1299	WP_181198552.1	amino acid permease	-
HV014_RS12275	2520956..2522167	-	1212	WP_181198553.1	sigma 54-interacting transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3912.73 Da
• Isoelectric Point: 9.0157

>T162432 WP_000170746.1 NZ_CP055599:c2517760-2517653 [Escherichia fergusonii]
MTLAELGMAFWHDLAAPVITGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

>T162432 NZ_CP071777:3521906-3522292 [Proteus mirabilis]
ATGGTTATTTATAAAACAAAGATGTTCAAAAATAGTTTCAAAAAAATAACGCTTACGAATGCAGAACTAATAGCTATTGC
TACCGAAGTCCTTGCAGGACAATTTGAGGCAGATCTAGGTGGTGGTGTTATCAAGAAACGTGCCTGTATCCAAGGAAAAG
GTAAAAGTAGCGGAATTAGAACAATTATATTTTATAAGCAAGGGAATAATTTATTCTTTGCTGATGGTTGGAAAAAATCG
AGTTTAAGCTCTAAAAAAACCAAAGAGATCACAGATGATGAACTTGAGTCCTATAAAGATCTAGCAAAAGATCTCTTCAA
TGCAAATCAAAATAAAATAGATAAAATGATTGCACTAGGCCTTTTAACAGAGGTTAAATATGACTGA

Antitoxin

Nucleotide

• Length: 64 bp

>AT162432 NZ_CP055599:2517809-2517872 [Escherichia fergusonii]
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Structures

Toxin

• AlphaFold DB: A0A826RQE3

Antitoxin