Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yafN-yafO (relBE)/YafO-YafN
Location 1712155..1712849 Replicon chromosome
Accession NZ_CP055599
Organism Escherichia fergusonii strain RHB41-C23

Toxin (Protein)


Gene name yafO Uniprot ID -
Locus tag HV014_RS08425 Protein ID WP_181199277.1
Coordinates 1712155..1712553 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name yafN Uniprot ID -
Locus tag HV014_RS08430 Protein ID WP_181199278.1
Coordinates 1712556..1712849 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV014_RS08395 1707283..1708740 + 1458 WP_181199274.1 cytosol nonspecific dipeptidase -
HV014_RS08400 1708749..1709030 + 282 WP_000106440.1 hypothetical protein -
HV014_RS08405 1709039..1709563 - 525 WP_141095971.1 metal-dependent hydrolase -
HV014_RS08410 1709625..1710239 - 615 Protein_1647 peptide chain release factor H -
HV014_RS08415 1710236..1711375 - 1140 WP_181199275.1 RNA ligase RtcB family protein -
HV014_RS08420 1711693..1712145 - 453 WP_181199276.1 GNAT family N-acetyltransferase -
HV014_RS08425 1712155..1712553 - 399 WP_181199277.1 type II toxin-antitoxin system mRNA interferase toxin YafO Toxin
HV014_RS08430 1712556..1712849 - 294 WP_181199278.1 type I toxin-antitoxin system antitoxin YafN Antitoxin
HV014_RS08435 1712901..1713956 - 1056 WP_181199279.1 DNA polymerase IV -
HV014_RS08440 1714027..1714813 - 787 Protein_1653 putative lateral flagellar export/assembly protein LafU -
HV014_RS08445 1714758..1716497 + 1740 WP_181199280.1 flagellar biosynthesis protein FlhA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1659664..1724969 65305


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin YafO

(27-130)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15530.91 Da        Isoelectric Point: 8.0934

>T162427 WP_181199277.1 NZ_CP055599:c1712553-1712155 [Escherichia fergusonii]
MRVFKTKLIRLQLTDKELDALTADFISYKRDGVLPDIFGRDALYDDSFTWPLIKFERVAHIHLANENNPFPPQLRQFSRT
NDEAHLVYCQGAFDEQAWLLIAILKPEPHKLARDNNQMHKIGKMAEAFRMRF

Download         Length: 399 bp

>T162427 NZ_CP071773:3521936-3522322 [Proteus mirabilis]
ATGGTTATTTATAAAACAAAGATGTTCAAAAATAGTTTCAAAAAAATAACGCTTACGAATGCAGAACTAATAGCTATTGC
TACCGAAGTCCTTGCAGGACAATTTGAGGCAGATCTAGGTGGTGGTGTTATCAAGAAACGTGCCTGTATCCAAGGAAAAG
GTAAAAGTAGCGGAATTAGAACAATTATATTTTATAAGCAAGGGAATAATTTATTCTTTGCTGATGGTTGGAAAAAATCG
AGTTTAAGCTCTAAAAAAACCAAAGAGATCACAGATGATGAACTTGAGTCCTATAAAGATCTAGCAAAAGATCTCTTCAA
TGCAAATCAAAATAAAATAGATAAAATGATTGCACTAGGCCTTTTAACAGAGGTTAAATATGACTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11165.69 Da        Isoelectric Point: 5.8944

>AT162427 WP_181199278.1 NZ_CP055599:c1712849-1712556 [Escherichia fergusonii]
MHRILAEKSVNITELRKNPAKYFIDQPVAVLSNNRPAGYLLSASAFEALMDMLAEQEEKKSIKARFRPSAARLEEITRRA
EQYLNDMTDDDFNGFKE

Download         Length: 294 bp

>AT162427 NZ_CP071773:3522315-3522635 [Proteus mirabilis]
ATGACTGATAAAATGAAAGAAATGCTAAAATTTGCACAAGAAATGGAAGATGCAGGAGTCACTGATGGCAGTACAACTAA
ACGTATTGCCGCCAGAATAAAAGCGAAAGAATTACAGGCTAAGTATAAACATCCTACCCCTATGACAGGTGAAGATATAA
AAAGGATCCGTGAGCAAAATAATATCTCTCAATCTTCCCTTGCTTTGATATTGAATATGACTAAAGAAAGCGTTTCTAAG
TGGGAAAGAAACGAAATTAAGCCCAATGGTGCAGCACTACGACTTCTGCATTTAATAGATAAAAAAATATTATTCATCTA
G

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References