Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1032425..1032927 Replicon chromosome
Accession NZ_CP055599
Organism Escherichia fergusonii strain RHB41-C23

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag HV014_RS05145 Protein ID WP_000767829.1
Coordinates 1032425..1032679 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag HV014_RS05150 Protein ID WP_001259255.1
Coordinates 1032676..1032927 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV014_RS05115 1027441..1027668 - 228 WP_000985273.1 sulfurtransferase TusA family protein -
HV014_RS05120 1027682..1028740 - 1059 WP_180491514.1 transport protein YeeE -
HV014_RS05125 1028919..1030277 - 1359 WP_000019201.1 putrescine/proton symporter PlaP -
HV014_RS05130 1030267..1030329 - 63 WP_010723108.1 membrane protein YoeI -
HV014_RS05135 1030543..1031472 - 930 WP_000803361.1 LysR family transcriptional regulator -
HV014_RS05140 1031518..1032342 - 825 WP_000754726.1 SDR family oxidoreductase -
HV014_RS05145 1032425..1032679 - 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
HV014_RS05150 1032676..1032927 - 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
HV014_RS05155 1033211..1033261 + 51 WP_001364200.1 his operon leader peptide -
HV014_RS05160 1033407..1034306 + 900 WP_000131779.1 ATP phosphoribosyltransferase -
HV014_RS05165 1034312..1035616 + 1305 WP_015953522.1 histidinol dehydrogenase -
HV014_RS05170 1035613..1036683 + 1071 WP_181199114.1 histidinol-phosphate transaminase -
HV014_RS05175 1036683..1037750 + 1068 WP_000080093.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T162425 WP_000767829.1 NZ_CP055599:c1032679-1032425 [Escherichia fergusonii]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T162425 NZ_CP071773:c13674-13291 [Proteus mirabilis]
ATGATATGGGTTAGCGCACAGGAAGTTATCGCTTTCCATGATCGTATATTACAACGTTTCCCAGGTGTGGCCGGTATGTC
CGATCCTGGCAGAGCGGAAGCTCTTATTTACCGGGTGCAAAACCGTAAACATTATGAAGGCATTACAGATGTGTTTGAAC
TGGCAGCAACTTATTGGGTCGCTATCGCTCGAGGGCACATATTTAATGACGGTAATAAACGTACCGCATTTTTTGTGACC
ATGACATTTCTCTATCGTAATGGCATCAGGATCCGCGATACTGGCAATATGCTGGAAAACTTAACAGTAGAAGCAGCTAC
AGGTGAGAAAACCGTCGACCAGTTAGCAAAACATCTACAAAACTTGGTAGAGAAAACTAACTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT162425 WP_001259255.1 NZ_CP055599:c1032927-1032676 [Escherichia fergusonii]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT162425 NZ_CP071773:c13892-13671 [Proteus mirabilis]
ATGCGTACATATACCTCGACACAAGCCCGAGCCAATATCTCAGAAGTATTAGATATTGCGACCCACGGTGAACCTGTTGA
AATCACCCGCAGAGACGGTTGTTCAGCGGTTGTTATCAGTAAAACTGAATTTGAGTCATACCAGAATGCTAAGCTAGATG
CAGAGTTTGATATGATGATGCAACGTCATGGACATACCGTAGAGGCACTGACAAATCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References