Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 476114..476676 Replicon chromosome
Accession NZ_CP055599
Organism Escherichia fergusonii strain RHB41-C23

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HV014_RS02340 Protein ID WP_104919749.1
Coordinates 476398..476676 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID S1PAQ1
Locus tag HV014_RS02335 Protein ID WP_000781370.1
Coordinates 476114..476398 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV014_RS02320 471473..474520 + 3048 WP_015953395.1 formate dehydrogenase-N subunit alpha -
HV014_RS02325 474533..475417 + 885 WP_001240580.1 formate dehydrogenase N subunit beta -
HV014_RS02330 475410..476063 + 654 WP_000045648.1 formate dehydrogenase-N subunit gamma -
HV014_RS02335 476114..476398 - 285 WP_000781370.1 HigA family addiction module antidote protein Antitoxin
HV014_RS02340 476398..476676 - 279 WP_104919749.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HV014_RS02345 476862..477872 - 1011 WP_181199002.1 alcohol dehydrogenase AdhP -
HV014_RS02350 478007..479704 - 1698 WP_181199003.1 malate dehydrogenase -
HV014_RS02355 479861..479998 - 138 WP_000841554.1 stationary-phase-induced ribosome-associated protein -
HV014_RS02360 480100..480315 - 216 WP_000495766.1 biofilm-dependent modulation protein -
HV014_RS02365 480658..481089 + 432 WP_000152299.1 peroxiredoxin OsmC -
HV014_RS02370 481150..481290 + 141 WP_109043809.1 omptin family outer membrane protease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-88)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10521.10 Da        Isoelectric Point: 7.3562

>T162422 WP_104919749.1 NZ_CP055599:c476676-476398 [Escherichia fergusonii]
MIMNFRHKGLRDLFLLGKTSGVIPTQVKRLRHRLAVIDAASCLADLDMPGYRLHPLSGDRDGIWAISVSGNWRITFEFVN
GDAYILDYEDYH

Download         Length: 279 bp

>T162422 NZ_CP071772:c71902-71600 [Acinetobacter towneri]
ATGTACTCAATATATACCACTGAAGTCTTTGATGACTGGTTTACTAAGTTAAAAGACCTGCAGGCAAAAAGACGTATACA
AGTCCGAATTGATCGGGTTGAAGATGGAAACTTTGGAGATACTGAACCAGTAGGTGAAGGTGTTTCTGAATTACGTTTCT
TCTTTGGACCTGGCTACAGGATCTATTACTGTAAGCAAGGGCAAAGGGTCGTTATTCTTTTAGCAGGCGGAGACAAGTCT
ACGCAAAGTAAAGATATAAAACTTGCCCTACAATTAGCACAAGATTTAGAGGAGGAGCTGTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10401.08 Da        Isoelectric Point: 8.8567

>AT162422 WP_000781370.1 NZ_CP055599:c476398-476114 [Escherichia fergusonii]
MKMANHPRPGDIIQESLDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPQMWLNLQNAWSLAEAE
KTVDVSRLRRLVTQ

Download         Length: 285 bp

>AT162422 NZ_CP071772:c71599-71318 [Acinetobacter towneri]
ATGGCTATCAAACTTCGCAAATGGGACAGTGCTGAACATCTTAAAACAGAAGAAGATATGCAAGCTTACCTACAAGCCTG
TATCGATGAATCTAATGGTGATGCGGCATTCATTGCAAAAGCTTTAGGTAATATTGCTAAAGCTAAAGGAATGGCTCAAT
TATCAAGAGACACTGGTTTAGGTCGAGAAAGTCTTTATAAAGCACTTTCTGGCGATGTAAATCCAAGCTTTGATACTGTT
ATTAAAGTCGTAAAAGCACTGAATTTACGCTTAGCAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 2ICT
PDB 2ICP
AlphaFold DB A0A829CUG6

References