Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 348653..349299 Replicon chromosome
Accession NZ_CP055509
Organism Klebsiella pneumoniae strain RHBSTW-00472

Toxin (Protein)


Gene name higB Uniprot ID A0A231WWF9
Locus tag HV207_RS01610 Protein ID WP_004174016.1
Coordinates 348653..349000 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A1F2LZT5
Locus tag HV207_RS01615 Protein ID WP_008806992.1
Coordinates 349000..349299 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV207_RS01600 344579..346012 + 1434 WP_002920564.1 glycogen synthase GlgA -
HV207_RS01605 346030..348477 + 2448 WP_002920561.1 glycogen phosphorylase -
HV207_RS01610 348653..349000 + 348 WP_004174016.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HV207_RS01615 349000..349299 + 300 WP_008806992.1 helix-turn-helix transcriptional regulator Antitoxin
HV207_RS01620 349362..350870 - 1509 WP_002920554.1 glycerol-3-phosphate dehydrogenase -
HV207_RS01625 351075..351404 + 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
HV207_RS01630 351455..352285 + 831 WP_004151408.1 rhomboid family intramembrane serine protease GlpG -
HV207_RS01635 352335..353093 + 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(31-84)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13518.55 Da        Isoelectric Point: 6.2327

>T162390 WP_004174016.1 NZ_CP055509:348653-349000 [Klebsiella pneumoniae]
MWDVETTDTFDAWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGNKDGMNEKRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp

>T162390 NZ_CP071766:2274280-2274573 [Acinetobacter towneri]
ATGACTTATAATCTTTTACGTCACAAGGACTTCACTGCAGAATGGGAAAAGCTTCCGAGTGCTATCCGCGACCAATTCAA
GAAAAAATTAGCCAAAGTCATTGAGCAGCCACATATTCCAAAGAACATGCTTAAAGGTGATCTTGCTGGCTGCTATAAAA
TCAAATTATTAAAAGCGGGTGTCCGACTTATTTATCAGGTCAAAGATGATCAGGTCGTTATTTTGCTCATTACCGTTGGA
AAGCGTGCTGATAACATTGTTTATGATGAAGCAAAAAAGCGGATCAAAGACTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10814.61 Da        Isoelectric Point: 10.1464

>AT162390 WP_008806992.1 NZ_CP055509:349000-349299 [Klebsiella pneumoniae]
MATLKELMAKQSPESQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQADNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp

>AT162390 NZ_CP071766:2274045-2274290 [Acinetobacter towneri]
ATGGCTACTGTTAATTTCAGGGTCGATGAAGCCCTTAAAGAAAAATCTTATTCAATCCTTAAAGAACAAGGTATCTCACC
TACCGATTTCTTTACCAATATTCTTGAATATGTGGCAACGACTGGAAAGCTTCCAGTACACAAAGCGTTGCTTTCAGAAG
AAGATGCTGAACTATTGGCACTTGTCCGTAAACGCATGAATGATCCTAAAGAGATGTTCGAGGAAGTCACATTAGATGAC
TTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A231WWF9

Antitoxin

Source ID Structure
AlphaFold DB A0A1F2LZT5

References