Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 95..634 Replicon plasmid unnamed
Accession NZ_CP055453
Organism Klebsiella pneumoniae strain RHBSTW-00574

Toxin (Protein)


Gene name yafQ Uniprot ID J2DZM3
Locus tag HV239_RS27130 Protein ID WP_004150484.1
Coordinates 359..634 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID A0A5H6MLU0
Locus tag HV239_RS27125 Protein ID WP_001570852.1
Coordinates 95..355 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV239_RS27125 95..355 + 261 WP_001570852.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HV239_RS27130 359..634 + 276 WP_004150484.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
HV239_RS27135 585..791 + 207 WP_162184628.1 hypothetical protein -
HV239_RS27140 803..1459 - 657 WP_166479947.1 hypothetical protein -
HV239_RS27145 1791..2318 + 528 WP_048242344.1 ankyrin repeat domain-containing protein -
HV239_RS27150 2329..2538 + 210 WP_048242343.1 hypothetical protein -
HV239_RS27155 2535..2834 + 300 WP_048242342.1 hypothetical protein -
HV239_RS27160 2831..3124 + 294 WP_048242341.1 hypothetical protein -
HV239_RS27165 3260..3571 + 312 WP_048242340.1 hypothetical protein -
HV239_RS27170 3574..4131 + 558 WP_053071116.1 prepilin-type N-terminal cleavage/methylation domain-containing protein -
HV239_RS27175 4147..4686 + 540 WP_045307794.1 prepilin-type N-terminal cleavage/methylation domain-containing protein -
HV239_RS27180 4703..4897 + 195 WP_048242338.1 hypothetical protein -
HV239_RS27185 4950..5396 - 447 WP_045351267.1 H-NS histone family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..41042 41042


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-83)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10750.40 Da        Isoelectric Point: 9.6586

>T162388 WP_004150484.1 NZ_CP055453:359-634 [Klebsiella pneumoniae]
MTTRTIEYSGQFQKDVKKAQKRHKDMSKLKALMTLLINDALPLPQVYKDHPLQGNYKGYRDAHIEPDWLLIYKITDEVLR
FERTGTHSDLF

Download         Length: 276 bp

>T162388 NZ_CP071766:c1819569-1819381 [Acinetobacter towneri]
ATGAACAGCAAAGACATTATTAAGCGTCTTGAGCAGGAAGGCTGGTACAAAGTGGGTGGTAAAGGCGACCATGAAAAGTA
TAAGCATCCTGAAAAGCCTGGACATGTTGTGGTACCACATCCACGTAAAGATATGCCAATAGGAACTCTACGCAATATAT
ATAAACAGGCTGGTTGGGAGTGGAGGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9239.63 Da        Isoelectric Point: 5.0336

>AT162388 WP_001570852.1 NZ_CP055453:95-355 [Klebsiella pneumoniae]
MAANAFVRARIDETLKNEAAVVLAGMGLTVSDLVRITLTKVAKEKALPFDMRVPNELTANTIANSEKGVDVHTAKDADDL
FNQLGI

Download         Length: 261 bp

>AT162388 NZ_CP071766:c1819378-1818995 [Acinetobacter towneri]
ATGTTATATCCAGTATATGTTCACAAAGATGAAGATAGCGCATACGGTTTAACCTTTCCTGACTTTGATGGATGCTTTAG
CGCAGCAGATGAGATGCAAGATATTCAGCGCATGGCACAGGAAGCGGTTGAAGTTCACTTTGATGGTGAAGATATTCCGT
TACCAGAACCATCAAGCCCAGAGCAATGGTTAGGTGATGAGCGATTTGAGGGGGGTTTTTGGTTGTTAGTTGATATTGAT
ACAACAAAAGTAAATACAAAGTCTATTCGTATTAATATCAGCATGCCAGAAGCTTTAGTGAAACGTATTGATGCTGTTGC
AAAAAAACAACATTTAAGCCGTTCGGCATTCTTAGCTAAAAGCGCGGAAATGGCGTTGCATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB J2DZM3

Antitoxin

Source ID Structure
AlphaFold DB A0A5H6MLU0

References