Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 350724..351370 Replicon chromosome
Accession NZ_CP055293
Organism Klebsiella pneumoniae strain 200

Toxin (Protein)


Gene name higB Uniprot ID A0A483JFR4
Locus tag HWA76_RS01615 Protein ID WP_004188313.1
Coordinates 350724..351071 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A483GM64
Locus tag HWA76_RS01620 Protein ID WP_004188315.1
Coordinates 351071..351370 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HWA76_RS01605 (346650) 346650..348083 + 1434 WP_002920564.1 glycogen synthase GlgA -
HWA76_RS01610 (348101) 348101..350548 + 2448 WP_234976294.1 glycogen phosphorylase -
HWA76_RS01615 (350724) 350724..351071 + 348 WP_004188313.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HWA76_RS01620 (351071) 351071..351370 + 300 WP_004188315.1 XRE family transcriptional regulator Antitoxin
HWA76_RS01625 (351433) 351433..352941 - 1509 WP_002920554.1 glycerol-3-phosphate dehydrogenase -
HWA76_RS01630 (353146) 353146..353475 + 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
HWA76_RS01635 (353526) 353526..354356 + 831 WP_004188317.1 rhomboid family intramembrane serine protease GlpG -
HWA76_RS01640 (354406) 354406..355164 + 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(31-78)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13548.57 Da        Isoelectric Point: 6.2327

>T162263 WP_004188313.1 NZ_CP055293:350724-351071 [Klebsiella pneumoniae]
MWDVETTDTFDTWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGNKDGMNEKRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp

>T162263 NZ_CP071706:c5429816-5429526 [Pseudomonas donghuensis]
ATGACCTATAGCCTTGAGTTCGATGCAAGGGCACTGAAGGAATGGCACAAGCTCGGCGACACCATACGTGCCCAGTTCAA
GAAGAAGCTGGCGGCTGTCTTGCTGGAGCCGCGAATCGAGGCCAATCGCCTTCGCAGTCTGCAGGATTGCTACAAAATAA
AGCTACGCAGCAGCGGCTATCGCTTGGTTTACCAAGTGATAGCTCAGGAGGTTGTGGTGTTCGTGGTGGCAGTGGACAAG
CGGGAGCGTGAGCAGGTGTACCGCAAGGCGTCTGAGCGATTGGCAGACTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10873.64 Da        Isoelectric Point: 10.1464

>AT162263 WP_004188315.1 NZ_CP055293:351071-351370 [Klebsiella pneumoniae]
MATLKELMAKQSPDSQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQADNDPRLSTLKRYIAAWG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp

>AT162263 NZ_CP071706:c5430045-5429806 [Pseudomonas donghuensis]
ATGGCGTCTATCAACGTTCGTATCGACGACGATCTTAAAGCCCGTGCCTACCGTGAGCTCGAAAAGCTCGGCGTTACGCC
TTCCGAACTGATGCGCCAGGCTTTGCAGTACGTCGCAGAGCGGGGCCAGCTGCCGTTCAAGCCGGTGCTGTTGACGGAGG
ATGACGAGGCTTTGCTCGCAACAGTACGCGAGCGGTTGGCTGCACCACAGCGAGTTAAGGTCGCTCTGGATGACCTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A483JFR4

Antitoxin

Source ID Structure
AlphaFold DB A0A483GM64

References