162249

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 3800922..3801424 Replicon chromosome
Accession NZ_CP055292
Organism Shigella sonnei strain SE6-1

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag HUX90_RS17925 Protein ID WP_000767829.1
Coordinates 3801170..3801424 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag HUX90_RS17920 Protein ID WP_001259255.1
Coordinates 3800922..3801173 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUX90_RS17895 3796100..3797167 - 1068 WP_000080095.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
HUX90_RS17900 3797167..3798237 - 1071 WP_053292574.1 histidinol-phosphate transaminase -
HUX90_RS17905 3798234..3799538 - 1305 WP_000009594.1 histidinol dehydrogenase -
HUX90_RS17910 3799544..3800443 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
HUX90_RS17915 3800589..3800639 - 51 WP_001364200.1 his operon leader peptide -
HUX90_RS17920 3800922..3801173 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
HUX90_RS17925 3801170..3801424 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
HUX90_RS17930 3801507..3802331 + 825 WP_000754737.1 SDR family oxidoreductase -
HUX90_RS17935 3802377..3803306 + 930 WP_053292573.1 LysR family transcriptional regulator -
HUX90_RS17940 3803521..3803583 + 63 WP_010723108.1 membrane protein YoeI -
HUX90_RS17945 3803573..3804931 + 1359 WP_024250698.1 putrescine/proton symporter PlaP -
HUX90_RS17950 3805110..3806168 + 1059 WP_000492311.1 transport protein YeeE -
HUX90_RS17955 3806182..3806409 + 228 WP_000985273.1 sulfurtransferase TusA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T162249 WP_000767829.1 NZ_CP055292:3801170-3801424 [Shigella sonnei]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T162249 NZ_CP071697:c1194169-1193384 [Streptococcus suis]
ATGAGGTTGGAAGAATTTAGTGAAGCTGAGTTTCAGAAGGCTTTACAGCGAACCATTCGGGCTTTAACCCGAGGAAAGAC
AATCCCAGTTCAACCGAAAGCTATCTTGCTTGGAGGACAAAGCGGGGCAGGTAAGACGACTATTCATCGAATTAAACAAA
AAGAATTTCAAGGTAATATCATTATCATCGATGGTGACAGCTATCGTTCTCAGCATCCCAATTACTTAGCACTGCAAGAA
AAGTATGGCAAGGACAGCGTGGACTATACCAAGGGATTTGCAGGAAAAATGGTAGAGCATCTGGTTGACGAACTCAGCAC
GCAGGGTTATCATTTGCTGATTGAAGGGACTTTGCGTACCACTCAAGTTCCTTGTCAGACTGCTCAATTACTCCGTTCTA
AAGGTTACCAAGTTTCCTTAGCTGTGATTGGTACCAAACCAGAATTGTCCTATCTCAGTACCTTGATTCGTTACGAAGAG
CTTTATACCATCGATCCCAATCAGGCCAGAGCAACACCAAAAGAACACCACGATGGGATTATAGAGAACTTGGTTGATAA
CCTAAGGGAGTTAGAAAGAGAGCAACTCTTTGATTGTATTCAGATTTATCAAAGAGACAGGACTTGTATTTATGATTCTA
AAACTGATAAAGATTCTGCAGCAGAAGTTCTTCAAAATTGCCTTTTCGGAGAGTGGAGTAAAGTAGAGGAAGAGATGATG
AAGTTAGGTCGGGAACGGTTACAGGAGTTAATTGAGGACAATATACTGCAAAATAATATTAAGTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT162249 WP_001259255.1 NZ_CP055292:3800922-3801173 [Shigella sonnei]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT162249 NZ_CP071697:c1194645-1194169 [Streptococcus suis]
ATGATTGGAGACAATATTAAATCACTACGTCGGACACACGAATTAACACAGCCAGAATTTGCGAAAATGATTGGTATTTC
ACGCAATAGCTTAAGTCGTTATGAGAATGGAACTAGTAAAGTTTCAACAGAACTTATCGACCGTATTTGTCAGAAATTTA
ACGTTTCTTATGTCGATATTGTAGGAGAGGACAAGATGCTAACACCTGTTGAAGATTACCAACTGACTTTAAAAATAGAA
GTGATAAAAGAACGTGGAGCAGCCATTTTATCACAGCTTTATAGATACCAGGATAGTCAAGATATTGCTTTTGATGATGA
ATCCAACCCTTGGATTTTGATGAGTGATGACTTGGCCGAATTGATTAACACAAAAATTTACCTTGTCGATACTTTCGATG
AAATAGAGCGCTACAATGGCTATTTAGACGGTATCGAGCGGATGTTAGACATGGTGCATCATCGGGTGGTGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LNR0

References