Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 3800922..3801424 Replicon chromosome
Accession NZ_CP055292
Organism Shigella sonnei strain SE6-1

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag HUX90_RS17925 Protein ID WP_000767829.1
Coordinates 3801170..3801424 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag HUX90_RS17920 Protein ID WP_001259255.1
Coordinates 3800922..3801173 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUX90_RS17895 3796100..3797167 - 1068 WP_000080095.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
HUX90_RS17900 3797167..3798237 - 1071 WP_053292574.1 histidinol-phosphate transaminase -
HUX90_RS17905 3798234..3799538 - 1305 WP_000009594.1 histidinol dehydrogenase -
HUX90_RS17910 3799544..3800443 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
HUX90_RS17915 3800589..3800639 - 51 WP_001364200.1 his operon leader peptide -
HUX90_RS17920 3800922..3801173 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
HUX90_RS17925 3801170..3801424 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
HUX90_RS17930 3801507..3802331 + 825 WP_000754737.1 SDR family oxidoreductase -
HUX90_RS17935 3802377..3803306 + 930 WP_053292573.1 LysR family transcriptional regulator -
HUX90_RS17940 3803521..3803583 + 63 WP_010723108.1 membrane protein YoeI -
HUX90_RS17945 3803573..3804931 + 1359 WP_024250698.1 putrescine/proton symporter PlaP -
HUX90_RS17950 3805110..3806168 + 1059 WP_000492311.1 transport protein YeeE -
HUX90_RS17955 3806182..3806409 + 228 WP_000985273.1 sulfurtransferase TusA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T162249 WP_000767829.1 NZ_CP055292:3801170-3801424 [Shigella sonnei]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T162249 NZ_CP071697:c1194169-1193384 [Streptococcus suis]
ATGAGGTTGGAAGAATTTAGTGAAGCTGAGTTTCAGAAGGCTTTACAGCGAACCATTCGGGCTTTAACCCGAGGAAAGAC
AATCCCAGTTCAACCGAAAGCTATCTTGCTTGGAGGACAAAGCGGGGCAGGTAAGACGACTATTCATCGAATTAAACAAA
AAGAATTTCAAGGTAATATCATTATCATCGATGGTGACAGCTATCGTTCTCAGCATCCCAATTACTTAGCACTGCAAGAA
AAGTATGGCAAGGACAGCGTGGACTATACCAAGGGATTTGCAGGAAAAATGGTAGAGCATCTGGTTGACGAACTCAGCAC
GCAGGGTTATCATTTGCTGATTGAAGGGACTTTGCGTACCACTCAAGTTCCTTGTCAGACTGCTCAATTACTCCGTTCTA
AAGGTTACCAAGTTTCCTTAGCTGTGATTGGTACCAAACCAGAATTGTCCTATCTCAGTACCTTGATTCGTTACGAAGAG
CTTTATACCATCGATCCCAATCAGGCCAGAGCAACACCAAAAGAACACCACGATGGGATTATAGAGAACTTGGTTGATAA
CCTAAGGGAGTTAGAAAGAGAGCAACTCTTTGATTGTATTCAGATTTATCAAAGAGACAGGACTTGTATTTATGATTCTA
AAACTGATAAAGATTCTGCAGCAGAAGTTCTTCAAAATTGCCTTTTCGGAGAGTGGAGTAAAGTAGAGGAAGAGATGATG
AAGTTAGGTCGGGAACGGTTACAGGAGTTAATTGAGGACAATATACTGCAAAATAATATTAAGTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT162249 WP_001259255.1 NZ_CP055292:3800922-3801173 [Shigella sonnei]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT162249 NZ_CP071697:c1194645-1194169 [Streptococcus suis]
ATGATTGGAGACAATATTAAATCACTACGTCGGACACACGAATTAACACAGCCAGAATTTGCGAAAATGATTGGTATTTC
ACGCAATAGCTTAAGTCGTTATGAGAATGGAACTAGTAAAGTTTCAACAGAACTTATCGACCGTATTTGTCAGAAATTTA
ACGTTTCTTATGTCGATATTGTAGGAGAGGACAAGATGCTAACACCTGTTGAAGATTACCAACTGACTTTAAAAATAGAA
GTGATAAAAGAACGTGGAGCAGCCATTTTATCACAGCTTTATAGATACCAGGATAGTCAAGATATTGCTTTTGATGATGA
ATCCAACCCTTGGATTTTGATGAGTGATGACTTGGCCGAATTGATTAACACAAAAATTTACCTTGTCGATACTTTCGATG
AAATAGAGCGCTACAATGGCTATTTAGACGGTATCGAGCGGATGTTAGACATGGTGCATCATCGGGTGGTGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References