Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 2600124..2600923 Replicon chromosome
Accession NZ_CP055292
Organism Shigella sonnei strain SE6-1

Toxin (Protein)


Gene name yhaV Uniprot ID F4VJD3
Locus tag HUX90_RS12340 Protein ID WP_000347266.1
Coordinates 2600124..2600588 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag HUX90_RS12345 Protein ID WP_001307405.1
Coordinates 2600588..2600923 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUX90_RS12310 2595125..2595559 - 435 WP_000948824.1 PTS sugar transporter subunit IIA -
HUX90_RS12315 2595577..2596455 - 879 WP_001315856.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
HUX90_RS12320 2596445..2597224 - 780 WP_000406214.1 PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC -
HUX90_RS12325 2597235..2597708 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
HUX90_RS12330 2597731..2599011 - 1281 WP_000681921.1 tagatose-bisphosphate aldolase subunit KbaZ -
HUX90_RS12335 2599260..2600069 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
HUX90_RS12340 2600124..2600588 - 465 WP_000347266.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
HUX90_RS12345 2600588..2600923 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
HUX90_RS12350 2601072..2602643 - 1572 WP_053292628.1 galactarate dehydratase -
HUX90_RS12355 2603018..2604352 + 1335 WP_053292629.1 galactarate/glucarate/glycerate transporter GarP -
HUX90_RS12360 2604368..2605138 + 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17841.18 Da        Isoelectric Point: 9.4947

>T162245 WP_000347266.1 NZ_CP055292:c2600588-2600124 [Shigella sonnei]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRFFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

>T162245 NZ_CP071696:2852416-2852841 [Agromyces archimandritae]
ATGATCGTCCTCGACACGAACGTCATCTCGGAGATCTTTCGGCCCTCGCCGGAGCCTCGTGTCGTCGAGTGGCTCGCTTC
GCTGACGGGCGACGTCGCGATCACCGCCATCACTCTCGCGGAGTTGCTTGCCGGTGTCCGAAGGCTCCCGGACGGCCGAC
GCAAAGACGAGCTGGCGCACGGGATCGAGGAAGCGGTAGCACTGTATCGGGGGAGCCGGTCGGTGCTCGCCTTCGATACT
GGCGCGGCGGAGCGATACGCGGAGGTGCTCGCGTCGCGTGAGGCAGCAGGTGCGCCGGTCAGTACCGCCGACGCCCAGAT
CGCCGCGATCTGCCTGGCGCACGGGGCAACCTGCGCTACGCGCAATGTGAAGGATTTCCAGCACACCGGCGTCGAACTCG
TGGACCCGTGGAATGTCAACGCGTGA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT162245 WP_001307405.1 NZ_CP055292:c2600923-2600588 [Shigella sonnei]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp

>AT162245 NZ_CP071696:2852186-2852419 [Agromyces archimandritae]
GTGTCATCCATCATCGTGCGTGGTCTCGATGACCACGTGAAGGAACAGCTCGCATCGCAGGCGAAGGAGCACGGGCGGTC
CATGGAGGCCGAGGTTCGAGACATCCTGACGAAGGCCGCTCGACGGCCGCACATCGGCATGGCTCTTCTGGCCGTGGCGC
GGGATGTCGGTGGGGCCGATGAGCTGCCGATTCCGACGCGCGATGATGTCGCACGGGCGGCGGACTTCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A836NGD2

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References