Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 3889664..3890463 Replicon chromosome
Accession NZ_CP055251
Organism Escherichia coli strain AH01

Toxin (Protein)


Gene name yhaV Uniprot ID U9XVR9
Locus tag HUU83_RS18750 Protein ID WP_000347267.1
Coordinates 3889664..3890128 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag HUU83_RS18755 Protein ID WP_001307405.1
Coordinates 3890128..3890463 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUU83_RS18720 3884665..3885099 - 435 WP_000948824.1 PTS sugar transporter subunit IIA -
HUU83_RS18725 3885117..3885995 - 879 WP_001295548.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
HUU83_RS18730 3885985..3886764 - 780 WP_000406214.1 PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC -
HUU83_RS18735 3886775..3887248 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
HUU83_RS18740 3887271..3888551 - 1281 WP_000681921.1 tagatose-bisphosphate aldolase subunit KbaZ -
HUU83_RS18745 3888800..3889609 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
HUU83_RS18750 3889664..3890128 - 465 WP_000347267.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
HUU83_RS18755 3890128..3890463 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
HUU83_RS18760 3890612..3892183 - 1572 WP_001273741.1 galactarate dehydratase -
HUU83_RS18765 3892558..3893892 + 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
HUU83_RS18770 3893908..3894678 + 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17807.17 Da        Isoelectric Point: 9.4947

>T162111 WP_000347267.1 NZ_CP055251:c3890128-3889664 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

>T162111 NZ_CP071586:c956669-956367 [Pseudomonas germanica]
ATGATCTCTTTTGAACGATCCCGCATATTTTCCGAATGGCTCGACTCCTTAAAAGACATCAAAGGGAAAGGCCGAATCAT
CTCCAGGATTAAAACAGCCGAACATGGCAACTTCGGCGATTGCGGCTTCGTCGGTGACACCGTTTATGAAATGCGTGTTC
ATTACGGCCCTGGTTACAGAATGTACTTCACACGTAAAGGCGAAGTGATTTATCTGCTGTTGATCGGGGGCGACAAATCG
ACACAAAAGAGAGATATCAAACGCGCCGTGCAAATGGCTCATAACATCGGAAATGAGGAGTAA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT162111 WP_001307405.1 NZ_CP055251:c3890463-3890128 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp

>AT162111 NZ_CP071586:c956363-956073 [Pseudomonas germanica]
ATGACCGAAGAATTCACCCGTTTTGACGCCGTCGAGTACCTTAAGACTCCCGAGGATATGGCGGCATATCTGGATGCCTG
TTTTGACGACGATGAAGGCGATGGCGTTCTGATTCGTGCAGCACTCAATGACATCGCCCGAGCTCAAGGCATGACACAAG
TGGCGCGGGATGCAGGTTTGGGCCGCGAAAGTCTTTATAAAGCGCTCAGTAGCACTGGCAATCCCGAATTCGCAACTATC
ATGAAAGTCATGAAGGCTCTGGGTTTGCGATTGCATGCCGTAACACTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XTR4

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References