162107

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2828104..2828606 Replicon chromosome
Accession NZ_CP055251
Organism Escherichia coli strain AH01

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag HUU83_RS13790 Protein ID WP_000767829.1
Coordinates 2828104..2828358 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag HUU83_RS13795 Protein ID WP_001259255.1
Coordinates 2828355..2828606 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUU83_RS13760 2823119..2823346 - 228 WP_000234896.1 sulfurtransferase TusA -
HUU83_RS13765 2823360..2824418 - 1059 Protein_2689 transport protein YeeE -
HUU83_RS13770 2824597..2825955 - 1359 WP_000019197.1 putrescine/proton symporter PlaP -
HUU83_RS13775 2825945..2826007 - 63 WP_010723108.1 membrane protein YoeI -
HUU83_RS13780 2826222..2827151 - 930 WP_000803366.1 LysR family transcriptional regulator -
HUU83_RS13785 2827197..2828021 - 825 WP_000754752.1 SDR family oxidoreductase -
HUU83_RS13790 2828104..2828358 - 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
HUU83_RS13795 2828355..2828606 - 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
HUU83_RS13800 2828890..2828940 + 51 WP_001364200.1 his operon leader peptide -
HUU83_RS13805 2829086..2829985 + 900 WP_000131782.1 ATP phosphoribosyltransferase -
HUU83_RS13810 2829991..2831295 + 1305 WP_039023537.1 histidinol dehydrogenase -
HUU83_RS13815 2831292..2832362 + 1071 WP_039023536.1 histidinol-phosphate transaminase -
HUU83_RS13820 2832362..2833429 + 1068 WP_000080077.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T162107 WP_000767829.1 NZ_CP055251:c2828358-2828104 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T162107 NZ_CP071523:48705-48863 [Escherichia coli]
ATGAAACTACCACGCAGCTCTCTTGTCTGGTGTGTGTTGATCGTGTGTCTCACACTGTTGATATTCACTTATCTGACACG
AAAATCGCTGTGCGAGATTCGTTACAGAGACGGATACAGGGAGGTGGCGGCTTTCATGGCTTACGAATCCGGTAAGTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT162107 WP_001259255.1 NZ_CP055251:c2828606-2828355 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT162107 NZ_CP071523:48441-48640 [Escherichia coli]
TCACAACGGATTGCCCGTAAACAGCCTGAATGAGCGAGTTATTTTCAGGAAAAGTGAATGTGGTCAGCGTGCTGGTATAT
GGGCTATGATGTGCCCGGCGCTTGAGGTTTTCTGCCTCATGACGTGAAGGTGGTTTGTTACCGTGTTGTGTGGCAGAAGG
ACAAAAGCCCCGTAGTTAATTTTTCATTAACCCACGAGGC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LNR0

References