162073

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2485879..2486441 Replicon chromosome
Accession NZ_CP055247
Organism Citrobacter freundii strain ZY198

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag GTH18_RS12030 Protein ID WP_032936429.1
Coordinates 2486163..2486441 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A8B5QC60
Locus tag GTH18_RS12025 Protein ID WP_003836231.1
Coordinates 2485879..2486163 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GTH18_RS12010 2483570..2484454 + 885 WP_003833024.1 formate dehydrogenase N subunit beta -
GTH18_RS12015 2484447..2485103 + 657 WP_003020054.1 formate dehydrogenase-N subunit gamma -
GTH18_RS12020 2485233..2485835 + 603 WP_032935729.1 inorganic diphosphatase -
GTH18_RS12025 2485879..2486163 - 285 WP_003836231.1 HigA family addiction module antidote protein Antitoxin
GTH18_RS12030 2486163..2486441 - 279 WP_032936429.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GTH18_RS12035 2486662..2488377 - 1716 WP_032935731.1 ATP-binding cassette domain-containing protein -
GTH18_RS12040 2488687..2490384 - 1698 WP_003020042.1 malate dehydrogenase -
GTH18_RS12045 2490564..2490704 - 141 WP_003020039.1 stationary-phase-induced ribosome-associated protein -
GTH18_RS12050 2490932..2491363 + 432 WP_003020036.1 peroxiredoxin OsmC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-83)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10667.30 Da        Isoelectric Point: 9.8965

>T162073 WP_032936429.1 NZ_CP055247:c2486441-2486163 [Citrobacter freundii]
MIMNFRHKGLRDLFLHGRTSGVMAKHVRRLRHRLAVIDAASKVTDINMPGYKLHPLVGDRDGIWAITVSGNWRITFEFVN
GDAYILDYEDYH

Download         Length: 279 bp

>T162073 NZ_CP071521:2611707-2611814 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10358.10 Da        Isoelectric Point: 8.8094

>AT162073 WP_003836231.1 NZ_CP055247:c2486163-2485879 [Citrobacter freundii]
MKMANHPRPGDIIQEALEELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPEMWLNLQTTWSLAEAQ
KSVDISRLRKLAVQ

Download         Length: 285 bp

>AT162073 NZ_CP071521:c2611660-2611594 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A8B5QC60

References