Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 3185362..3185620 Replicon chromosome
Accession NZ_CP055227
Organism Erwinia amylovora strain Ea1189

Toxin (Protein)


Gene name hok Uniprot ID D4I1C1
Locus tag GTU81_RS14545 Protein ID WP_004160031.1
Coordinates 3185362..3185520 (-) Length 53 a.a.

Antitoxin (RNA)


Gene name sok
Locus tag -
Coordinates 3185574..3185620 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GTU81_RS14530 3180667..3182358 - 1692 WP_004160025.1 chloride channel protein -
GTU81_RS14535 3182771..3183751 + 981 WP_013035818.1 TerC family protein -
GTU81_RS14540 3183986..3185218 + 1233 WP_004160030.1 serine/threonine transporter SstT -
GTU81_RS14545 3185362..3185520 - 159 WP_004160031.1 type I toxin-antitoxin system Hok family toxin Toxin
- 3185574..3185620 + 47 - - Antitoxin
GTU81_RS14550 3186331..3187005 + 675 WP_004160034.1 DedA family protein -
GTU81_RS14555 3187002..3187394 + 393 WP_004160035.1 EnvZ/OmpR regulon moderator MzrA -
GTU81_RS14560 3187562..3187933 + 372 WP_004160036.1 DUF1090 domain-containing protein -
GTU81_RS14565 3187976..3188281 + 306 WP_004160037.1 DUF883 family protein -
GTU81_RS14570 3188283..3188675 + 393 WP_004160038.1 phage holin family protein -
GTU81_RS14575 3188675..3188956 + 282 WP_004160039.1 YqjK-like family protein -
GTU81_RS14580 3189166..3189558 + 393 WP_004160048.1 DoxX family protein -
GTU81_RS14585 3190031..3190174 + 144 WP_004160049.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(8-48)


Sequences

Toxin        


Download         Length: 53 a.a.        Molecular weight: 6038.32 Da        Isoelectric Point: 8.4901

>T162050 WP_004160031.1 NZ_CP055227:c3185520-3185362 [Erwinia amylovora]
MKLPANCLIWCVLIVCVTLLIFTYLTRKSLCEIRYKDGYREVAAFMAYESGK

Download         Length: 159 bp

>T162050 NZ_CP071505:958291-958440 [Staphylococcus haemolyticus]
ATGACTAAAAATAAAGATTCAGAATTAAATTATCATGAGGAAGAAAATGCGATGGTTCAAGATTTAGATGACTTGAAAAC
ATTGGGCAAAGAAATGGAACAAATTTCTGAAGAAAACGACGAGGACAGGTTGAATCAATCGCATGAGTAA

Antitoxin


Download         Length: 47 bp

>AT162050 NZ_CP055227:3185574-3185620 [Erwinia amylovora]
GCATGCAGATGGCCTCGTGGATTAATGAAAATTAACTACGGGGCTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A831A7I1

Antitoxin

Download structure file

References