Detailed information of TA system TA162050

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 3185362..3185620
• Replicon: chromosome
• Accession: NZ_CP055227
• Organism: Erwinia amylovora strain Ea1189

Toxin (Protein)

• Gene name: hok
• Uniprot ID: D4I1C1
• Locus tag: GTU81_RS14545
• Protein ID: WP_004160031.1
• Coordinates: 3185362..3185520 (-)
• Length: 53 a.a.

Antitoxin (RNA)

Gene name	sok
Locus tag	-
Coordinates	3185574..3185620 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GTU81_RS14530	3180667..3182358	-	1692	WP_004160025.1	chloride channel protein	-
GTU81_RS14535	3182771..3183751	+	981	WP_013035818.1	TerC family protein	-
GTU81_RS14540	3183986..3185218	+	1233	WP_004160030.1	serine/threonine transporter SstT	-
GTU81_RS14545	3185362..3185520	-	159	WP_004160031.1	type I toxin-antitoxin system Hok family toxin	Toxin
-	3185574..3185620	+	47	-	-	Antitoxin
GTU81_RS14550	3186331..3187005	+	675	WP_004160034.1	DedA family protein	-
GTU81_RS14555	3187002..3187394	+	393	WP_004160035.1	EnvZ/OmpR regulon moderator MzrA	-
GTU81_RS14560	3187562..3187933	+	372	WP_004160036.1	DUF1090 domain-containing protein	-
GTU81_RS14565	3187976..3188281	+	306	WP_004160037.1	DUF883 family protein	-
GTU81_RS14570	3188283..3188675	+	393	WP_004160038.1	phage holin family protein	-
GTU81_RS14575	3188675..3188956	+	282	WP_004160039.1	YqjK-like family protein	-
GTU81_RS14580	3189166..3189558	+	393	WP_004160048.1	DoxX family protein	-
GTU81_RS14585	3190031..3190174	+	144	WP_004160049.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (8-48)

Sequences

Toxin

Protein

• Length: 53 a.a.
• Molecular weight: 6038.32 Da
• Isoelectric Point: 8.4901

>T162050 WP_004160031.1 NZ_CP055227:c3185520-3185362 [Erwinia amylovora]
MKLPANCLIWCVLIVCVTLLIFTYLTRKSLCEIRYKDGYREVAAFMAYESGK

Nucleotide

• Length: 159 bp

>T162050 NZ_CP071505:958291-958440 [Staphylococcus haemolyticus]
ATGACTAAAAATAAAGATTCAGAATTAAATTATCATGAGGAAGAAAATGCGATGGTTCAAGATTTAGATGACTTGAAAAC
ATTGGGCAAAGAAATGGAACAAATTTCTGAAGAAAACGACGAGGACAGGTTGAATCAATCGCATGAGTAA

Antitoxin

Nucleotide

• Length: 47 bp

>AT162050 NZ_CP055227:3185574-3185620 [Erwinia amylovora]
GCATGCAGATGGCCTCGTGGATTAATGAAAATTAACTACGGGGCTTT

Structures

Toxin

• AlphaFold DB: A0A831A7I1

Antitoxin