Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2588563..2589086 Replicon chromosome
Accession NZ_CP055225
Organism Staphylococcus aureus LAC

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag HUW68_RS13015 Protein ID WP_000074048.1
Coordinates 2588563..2588829 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag HUW68_RS13020 Protein ID WP_000587616.1
Coordinates 2588829..2589086 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUW68_RS12995 2583870..2585057 - 1188 WP_000026194.1 MFS transporter -
HUW68_RS13000 2585453..2586229 - 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
HUW68_RS13005 2586222..2586884 - 663 WP_000923520.1 ATP-binding cassette domain-containing protein -
HUW68_RS13010 2587132..2588208 - 1077 WP_001076671.1 M42 family metallopeptidase -
HUW68_RS13015 2588563..2588829 - 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
HUW68_RS13020 2588829..2589086 - 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HUW68_RS13025 2589192..2589386 - 195 WP_001790145.1 hypothetical protein -
HUW68_RS13030 2589445..2589900 + 456 WP_000732082.1 DUF1307 domain-containing protein -
HUW68_RS13035 2590068..2591645 - 1578 WP_000143503.1 FMN-binding glutamate synthase family protein -
HUW68_RS13040 2591840..2592589 + 750 WP_000072444.1 hypothetical protein -
HUW68_RS13045 2592813..2594006 - 1194 WP_000675401.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T162042 WP_000074048.1 NZ_CP055225:c2588829-2588563 [Staphylococcus aureus LAC]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T162042 NZ_CP071491:1658192-1658368 [Glaesserella parasuis]
ATGAAACAAAGTGAATTTTTAAGATGGCTAATTGCTCAAGGGGTAGTAAAGGAAGAAGGCTCAAAGCACATCAAACTTTA
TTACAACGGTAATCAATCAACAATGCCAAGACAACCTAGCAAGGAAATCAAAAACGGCACAATGAGAGCGATTAAAAAGC
AATTAGGTTTAAACTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT162042 WP_000587616.1 NZ_CP055225:c2589086-2588829 [Staphylococcus aureus LAC]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT162042 NZ_CP071491:1658415-1658828 [Glaesserella parasuis]
ATGCTGTATCCAGCACGATTCGAATTTGAAGATGGTAGTTATAATGTTTCATTCCGTGATATTCCTGAAGCGTTGACTTG
CGGTGATAACTACGAAGACGCTTTAGAGATGGCAAAAGATGCATTGCTTACCAGTATGGATTTTTATTTCGAAGATCATC
GCAAAGTACCGTTACCAAGCCCACCACAAGAAGGCGAAGTGCTGATCGAATTACCGACAAGTATTTTCGCCAAAGTGCTA
TTGCTAAATGAGATGGTCGATCAGAATATCTCCAATGTGGAATTAGCAAAACGAATTGCCGTAAAACCGCAAGAAGTACA
GCGTATTACTAATCTTGGGCATAGTACAAAAATCGATACTATTGCAAGAGCGATTAATGCACTCGACAAACAGTTTGAAT
TACGTGTTGTCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
PDB 7V6W
PDB 7V5Z
PDB 7V5Y
AlphaFold DB W8TQT5

References