Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2531715..2532232 Replicon chromosome
Accession NZ_CP055225
Organism Staphylococcus aureus LAC

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag HUW68_RS12740 Protein ID WP_000113262.1
Coordinates 2531715..2531981 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A5A8VWS3
Locus tag HUW68_RS12745 Protein ID WP_000584502.1
Coordinates 2531981..2532232 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUW68_RS12710 2527141..2527677 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
HUW68_RS12715 2527910..2528734 - 825 WP_000572040.1 formate/nitrite transporter family protein -
HUW68_RS12720 2528951..2529133 - 183 WP_000230294.1 hypothetical protein -
HUW68_RS12725 2529217..2529684 - 468 WP_000153344.1 SRPBCC domain-containing protein -
HUW68_RS12730 2529870..2531420 - 1551 WP_000727762.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
HUW68_RS12735 2531609..2531680 - 72 Protein_2464 hypothetical protein -
HUW68_RS12740 2531715..2531981 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
HUW68_RS12745 2531981..2532232 - 252 WP_000584502.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HUW68_RS12750 2532397..2532498 - 102 WP_001791744.1 hypothetical protein -
HUW68_RS12755 2532505..2533104 - 600 WP_000162813.1 DsbA family protein -
HUW68_RS12760 2533123..2533482 - 360 WP_000819847.1 DUF4467 domain-containing protein -
HUW68_RS12765 2533737..2534987 + 1251 WP_001012222.1 FemA/FemB family glycyltransferase FmhA -
HUW68_RS12770 2535084..2535815 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
HUW68_RS12775 2535812..2536531 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T162039 WP_000113262.1 NZ_CP055225:c2531981-2531715 [Staphylococcus aureus LAC]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T162039 NZ_CP071491:1193724-1194002 [Glaesserella parasuis]
ATGATTATTTCATTTAAGCATAAAGGATTGAAATTATTTTTTGAAACAGGATCAACTGCAGGTATTCAGGCGAATCACGC
TAGTAAACTTGCTTTTCAATTAGCCACTCTAAACCAAGCAAAAAGTGCTTTAGATATGAATGCACCTAGCTGGAATTTAC
ATCAATTACAAGGTAATCTAGCTGGGCATTGGTCTATCAAGGTAAGTGGAAATTGGCGTTTAACTTTTAAATTTCAAAAT
GGTCACGCTGAAGTCGTGGACTATCAAGATTATCATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9417.65 Da        Isoelectric Point: 4.4702

>AT162039 WP_000584502.1 NZ_CP055225:c2532232-2531981 [Staphylococcus aureus LAC]
MIIKNYSYARQNLKALMTKVNDDSVMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT162039 NZ_CP071491:1194013-1194285 [Glaesserella parasuis]
ATGAAAATGTACAATCCAGCTCACCCAGGGCTTATTTTAAGAGAATATATTGAAGGATATAATGTCACAGAAGTGGCTAA
ACGTTTAGGTGTCACTCGTGTCACGCTTTCTCGTATTTTAAATGGCAAAGCTGCAATTTCACCTGAAATGGCTCTTAGAT
TAAGCCAATTATTAAAAACTAGCCCAGAATTATGGCTTGGTTTACAATCCCAATACGATCTTTGGCAGCTTGAACAACGC
CCAAGTTTTAATATTCAGCCGTTATTTGCATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
AlphaFold DB A0A5A8VWS3

References