Detailed information of TA system TA162037

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2266961..2267224
• Replicon: chromosome
• Accession: NZ_CP055225
• Organism: Staphylococcus aureus LAC

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: HUW68_RS11355
• Protein ID: WP_001802298.1
• Coordinates: 2267120..2267224 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF4
Locus tag	-
Coordinates	2266961..2267125 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HUW68_RS11335	2263144..2263809	-	666	WP_001024094.1	SDR family oxidoreductase	-
HUW68_RS11340	2263961..2264281	+	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
HUW68_RS11345	2264283..2265263	+	981	WP_000019744.1	CDF family zinc efflux transporter CzrB	-
HUW68_RS11350	2265529..2266620	+	1092	WP_000495671.1	lytic regulatory protein	-
-	2266961..2267125	+	165	-	-	Antitoxin
HUW68_RS11355	2267120..2267224	-	105	WP_001802298.1	hypothetical protein	Toxin
HUW68_RS11360	2267385..2267868	-	484	Protein_2198	recombinase family protein	-
HUW68_RS11365	2267911..2269047	-	1137	WP_000115564.1	SAP domain-containing protein	-
HUW68_RS11370	2269336..2269428	+	93	WP_001790138.1	hypothetical protein	-
HUW68_RS11375	2270133..2270990	-	858	WP_000370924.1	Cof-type HAD-IIB family hydrolase	-
HUW68_RS11380	2271058..2271840	-	783	WP_000908176.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T162037 WP_001802298.1 NZ_CP055225:c2267224-2267120 [Staphylococcus aureus LAC]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T162037 NZ_CP071491:c639746-639402 [Glaesserella parasuis]
ATGACTACTCAAGAGTATATCCCTGACGTTGGTGATATTATTTGGCTTGATTTTGATCCGCAAGCAGGACATGAACAAGC
TGGCCATCGTCCAGCATTAGTGTTAACGCCCACGATTTATAATCGTCAAACAGGGTTGTTAATTTGCTGCCCGCTCACAA
CAAAAGTAAAAGGCTATCCTTTCGAAGTCAATATTGCAGGTACCCCCCAAAATGTTGTGCTTTCCGATCAAATTAAAAGC
CTTGACTGGCGTATTCGTCACGCTAAATTTAAAGGTAAAATTAACCATCATCAGTTAAGCGAAGTAAAAGCTAAAATTGC
GACTTTGCTACAAATCAGTGAATAA

Antitoxin

Nucleotide

• Length: 165 bp

>AT162037 NZ_CP055225:2266961-2267125 [Staphylococcus aureus LAC]
GTAGTAAGTAGAAGCAAAAGATGAAAATCATTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTCAAAGCGAATAGAAGGT
TATTT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin