Detailed information of TA system TA162031

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 2092337..2092636
• Replicon: chromosome
• Accession: NZ_CP055225
• Organism: Staphylococcus aureus LAC

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: HUW68_RS10365
• Protein ID: WP_011447039.1
• Coordinates: 2092460..2092636 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2092337..2092392 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HUW68_RS10325	2087668..2087928	+	261	WP_001791826.1	hypothetical protein	-
HUW68_RS10330	2087981..2088331	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
HUW68_RS10335	2089016..2089465	+	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
HUW68_RS10340	2089560..2089895	-	336	Protein_1999	SH3 domain-containing protein	-
HUW68_RS10345	2090545..2091036	-	492	WP_000919350.1	staphylokinase	-
HUW68_RS10350	2091227..2091982	-	756	WP_000861038.1	CHAP domain-containing protein	-
HUW68_RS10355	2091994..2092248	-	255	WP_000611512.1	phage holin	-
HUW68_RS10360	2092300..2092407	+	108	WP_001791821.1	hypothetical protein	-
-	2092329..2092468	+	140	NuclAT_0	-	-
-	2092329..2092468	+	140	NuclAT_0	-	-
-	2092329..2092468	+	140	NuclAT_0	-	-
-	2092329..2092468	+	140	NuclAT_0	-	-
-	2092337..2092392	+	56	-	-	Antitoxin
HUW68_RS10365	2092460..2092636	-	177	WP_011447039.1	putative holin-like toxin	Toxin
HUW68_RS10370	2092786..2093082	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
HUW68_RS10375	2093140..2093427	-	288	WP_001040261.1	hypothetical protein	-
HUW68_RS10380	2093474..2093626	-	153	WP_001153681.1	hypothetical protein	-
HUW68_RS10385	2093616..2097401	-	3786	WP_000582165.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / chp / sak / hlb / groEL	2087981..2146949	58968

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T162031 WP_011447039.1 NZ_CP055225:c2092636-2092460 [Staphylococcus aureus LAC]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T162031 NZ_CP071490:1403139-1403639 [Glaesserella parasuis]
ATGAAGAGTAAGTTTATTGAAGAGCCTTTAACGAAGCATCATCAACGTGAAGCCTTTGATTGCGGAAATCTAGAGATGAA
CCGATTTTTTAAACAATACGCTCGGCAATCTCACGAAAAAGGGACATCAAAAACTTACATTAGCCGACACTTAGACAGTC
AACAGATTATCGGATTTTATACAATCACCTTAAGTGCATTAGACCAGCAACACTTACCCGAACTATGCAAAAAACGTTTT
GGCTACCACCCTATTCCGCTCTTTACATTAGCAAGACTTGCAGTGGATATTCGCTATCAAAAACAAGGCATTGGCGGAAT
GCTGTTGGTTAAAGCTCTCAAACGCTGTGCCATCGTTGCCGAACAAGTCGGGGGAATTGGGCTTCTCATTGAAGCAAAAG
ATGAAGACATTTCTCGTTGGTATCAATCTTATGGTGCTATTCCATTGGAAAATATGCCATTAACCTTAATTCTACTCTTT
GATACAATCAAAGGACTTTAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT162031 NZ_CP055225:2092337-2092392 [Staphylococcus aureus LAC]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• PDB: 7NS1

Antitoxin