162024

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 4797528..4798879 Replicon chromosome
Accession NZ_CP055224
Organism Pectobacterium atrosepticum strain Green1

Toxin (Protein)


Gene name HipT Uniprot ID -
Locus tag HLB43_RS21300 Protein ID WP_039296545.1
Coordinates 4797839..4798879 (+) Length 347 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID -
Locus tag HLB43_RS21295 Protein ID WP_039296542.1
Coordinates 4797528..4797842 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HLB43_RS21270 (HLB43_21260) 4793356..4794492 + 1137 WP_039296529.1 alkylhydroperoxidase domain protein -
HLB43_RS21275 (HLB43_21265) 4794899..4795336 + 438 WP_039296533.1 RICIN domain-containing protein -
HLB43_RS21280 (HLB43_21270) 4795573..4796082 - 510 WP_011091713.1 phenolic acid decarboxylase -
HLB43_RS21285 (HLB43_21275) 4796185..4797057 + 873 WP_039296537.1 LysR family transcriptional regulator -
HLB43_RS21290 (HLB43_21280) 4797217..4797543 + 327 WP_039296540.1 helix-turn-helix domain-containing protein -
HLB43_RS21295 (HLB43_21285) 4797528..4797842 + 315 WP_039296542.1 HipA N-terminal domain-containing protein Antitoxin
HLB43_RS21300 (HLB43_21290) 4797839..4798879 + 1041 WP_039296545.1 HipA domain-containing protein Toxin
HLB43_RS21305 (HLB43_21295) 4798940..4799563 - 624 WP_039296550.1 LysE family translocator -
HLB43_RS21310 (HLB43_21300) 4799784..4800539 + 756 WP_039296553.1 thiol:disulfide interchange protein DsbG -
HLB43_RS21315 (HLB43_21305) 4800574..4801479 - 906 WP_039296557.1 siderophore-interacting protein -
HLB43_RS21320 (HLB43_21310) 4801735..4801986 + 252 WP_010281712.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
HLB43_RS21325 (HLB43_21315) 4801983..4802270 + 288 WP_011091708.1 type II toxin-antitoxin system RelE/ParE family toxin -
HLB43_RS21330 (HLB43_21320) 4802373..4803725 - 1353 WP_215216058.1 glutathione-disulfide reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(57-307)

Antitoxin

HipA, N-terminal subdomain 1

(5-98)


Sequences

Toxin        


Download         Length: 347 a.a.        Molecular weight: 39575.52 Da        Isoelectric Point: 6.5563

>T162024 WP_039296545.1 NZ_CP055224:4797839-4798879 [Pectobacterium atrosepticum]
MTRCRILLTPLAHEEEIATGYSRKGLKHLAGSIHASPTLRFTRQQFMHDLPQTQKGMSISGYQPKIQMVLEDRTFTVVDH
QGLYILKPSPIEFPHLAENEHATMTLMARLGFAVPPHGLLRFKPEQMDDESEFAFVIKRFDRDEKTGHPIHQEQLDGAMG
IGEKFGKIRADGRQYVSYERLALFLSEHVNDNIVFKIDLFRRIAYTYMLGNNDMHLRNFGLIHSRSGQLMLAPIYDFVSV
APYPAYFSSCFMALPLLIQEEGDEALAPGFETAYGEYLGMDFMLFGQHIGLSENLTRKLLADLIKEAEYVESTYRDSFMP
ANAIDATLRCYRHRLNLMSVLDAKQI

Download         Length: 1041 bp

>T162024 NZ_CP071489:1623665-1624009 [Glaesserella parasuis]
ATGACTACTCAAGAGTATATCCCTGACGTTGGTGATATTATTTGGCTTGATTTTGATCCGCAAGCAGGACATGAACAAGC
TGGCCATCGTCCAGCATTAGTGTTAACGCCCACGATTTATAATCGTCAAACAGGGTTGTTAATTTGCTGCCCGCTCACAA
CAAAAGTAAAAGGCTATCCTTTCGAAGTCAATATTGCAGGTACCCCCCAAAATGTTGTGCTTTCCGATCAAATTAAAAGC
CTTGACTGGCGTATTCGTCACGCTAAATTTAAAGGTAAAATTAACCATCATCAGTTAAGCGAAGTAAAAGCTAAAATTGC
GACTTTGCTACAAATCAGTGAATAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11869.67 Da        Isoelectric Point: 9.2317

>AT162024 WP_039296542.1 NZ_CP055224:4797528-4797842 [Pectobacterium atrosepticum]
VRRQVKVYLYGVHIGQLSQDDEGYLFEYKKSYLGPPLSLSLPLQTGIFRSKSLLPYFASLAPEGWLRRQYSQLQHLDEKD
LFGILIQNGKNLIGAVQLIAEDKS

Download         Length: 315 bp

>AT162024 NZ_CP071489:1623429-1623668 [Glaesserella parasuis]
ATGCAAGTGGCTGTCAAAAAATGGGGAAATAGCGTAGGCATTCGCATTCCTGCTTTATTATCTAATTCATTGAAATTACA
GGCAGAGAGTTTAGTCGATATTCAAGAAGTTGATGGTCGCCTAATTATTGAGCCGATTAAACCTAAATATAATTTAGAGC
AACTTCTTTCAGGTATTACTGAAGATAATTTGCACAATGAAGTCGATTTTGGCAAGCCTGTTGGCAAGGAAATGCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References