Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 4353842..4354344 Replicon chromosome
Accession NZ_CP055224
Organism Pectobacterium atrosepticum strain Green1

Toxin (Protein)


Gene name yoeB Uniprot ID Q6DA20
Locus tag HLB43_RS19260 Protein ID WP_011092065.1
Coordinates 4354090..4354344 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID Q6DA19
Locus tag HLB43_RS19255 Protein ID WP_011092066.1
Coordinates 4353842..4354093 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HLB43_RS19240 (HLB43_19230) 4350243..4351202 + 960 WP_011092069.1 ABC transporter permease -
HLB43_RS19245 (HLB43_19235) 4351195..4352061 + 867 WP_011092068.1 ABC transporter permease -
HLB43_RS19250 (HLB43_19240) 4352058..4353767 + 1710 WP_011092067.1 ABC transporter ATP-binding protein -
HLB43_RS19255 (HLB43_19245) 4353842..4354093 + 252 WP_011092066.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
HLB43_RS19260 (HLB43_19250) 4354090..4354344 + 255 WP_011092065.1 Txe/YoeB family addiction module toxin Toxin
HLB43_RS19265 (HLB43_19255) 4354386..4355240 - 855 WP_039289761.1 helix-turn-helix domain-containing protein -
HLB43_RS19270 (HLB43_19260) 4355265..4356104 - 840 WP_011092063.1 HTH-type transcriptional activator RhaS -
HLB43_RS19275 (HLB43_19265) 4356421..4357911 + 1491 WP_011092062.1 rhamnulokinase -
HLB43_RS19280 (HLB43_19270) 4357908..4359170 + 1263 WP_011092061.1 L-rhamnose isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10141.67 Da        Isoelectric Point: 8.8560

>T162022 WP_011092065.1 NZ_CP055224:4354090-4354344 [Pectobacterium atrosepticum]
VKLIWSEEAWEDYLYWQDIDKRTVKKINELIKETRRTPFEGKGKPEPLKHNLAGFWSRRITEAHRLVYAITDDAMMIAAC
RYHY

Download         Length: 255 bp

>T162022 NZ_CP071489:c1070416-1070138 [Glaesserella parasuis]
ATGATTATTTCATTTAAGCATAAAGGATTGAAATTATTTTTTGAAACAGGATCAACTGCAGGTATTCAGGCAAATCACGC
TAGTAAACTTGCTTTTCAATTAGCCACTCTAAACCAAGCAAAAAGTGCTTTAGATATGAATGCACCTAGCTGGAATTTAC
ATCAATTACAAGGTAATCTAGCTGGGCATTGGTCTATCAAGGTAAGTGGAAATTGGCGTTTAACTTTTAAATTTCAAAAT
GGTCACGCTGAAGTCGTGGACTATCAAGATTATCATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9397.66 Da        Isoelectric Point: 4.6119

>AT162022 WP_011092066.1 NZ_CP055224:4353842-4354093 [Pectobacterium atrosepticum]
MRTISYSEARQNLSATMMKTVEDRAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANAKRLMNSIESLKAGNSEERD
IIE

Download         Length: 252 bp

>AT162022 NZ_CP071489:c1070127-1069855 [Glaesserella parasuis]
ATGAAAATGTACAATCCAGCTCACCCAGGGCTTATTTTAAGAGAATATATTGAAGGATATAATGTCACAGAAGTGGCTAA
ACGTTTAGGTGTCACTCGTGTCACGCTTTCTCGTATTTTAAATGGCAAAGCTGCAATTTCACCTGAAATGGCTCTTAGAT
TAAGCCAATTATTAAAAACTAGCCCAGAATTATGGCTTGGTTTACAATCCCAATACGATCTTTGGCAGCTTGAACAACGC
CCAAGTTTTAATATTCAGCCGTTATTTGCATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q6DA20

Antitoxin

Source ID Structure
AlphaFold DB Q6DA19

References