Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 26449..27106 Replicon chromosome
Accession NZ_CP055224
Organism Pectobacterium atrosepticum strain Green1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HLB43_RS00120 Protein ID WP_039294444.1
Coordinates 26735..27106 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HLB43_RS00115 Protein ID WP_039294447.1
Coordinates 26449..26748 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HLB43_RS00095 (HLB43_00095) 21719..22690 + 972 WP_039294457.1 nucleoside hydrolase -
HLB43_RS00100 (HLB43_00100) 22690..23667 + 978 WP_039294455.1 ABC transporter permease -
HLB43_RS00105 (HLB43_00105) 23664..24572 + 909 WP_039294453.1 ABC transporter permease -
HLB43_RS00110 (HLB43_00110) 24612..26411 + 1800 WP_039294450.1 ABC transporter ATP-binding protein -
HLB43_RS00115 (HLB43_00115) 26449..26748 - 300 WP_039294447.1 XRE family transcriptional regulator Antitoxin
HLB43_RS00120 (HLB43_00120) 26735..27106 - 372 WP_039294444.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HLB43_RS00125 (HLB43_00125) 27513..28211 + 699 WP_039294441.1 D-galactonate utilization transcriptional regulator DgoR -
HLB43_RS00130 (HLB43_00130) 28208..29104 + 897 WP_039294438.1 2-dehydro-3-deoxygalactonokinase -
HLB43_RS00135 (HLB43_00135) 29088..29705 + 618 WP_039294435.1 2-dehydro-3-deoxy-6-phosphogalactonate aldolase -
HLB43_RS00140 (HLB43_00140) 29702..30850 + 1149 WP_039294433.1 galactonate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(14-108)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-80)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 14160.08 Da        Isoelectric Point: 4.8590

>T162015 WP_039294444.1 NZ_CP055224:c27106-26735 [Pectobacterium atrosepticum]
MAWKIVTRDLFDTWFDEQTEAVQEEVLAHLAILEEDGPQLGRPQVDQIKGSKYKNMKELRVQVGGHPFRTFFAFDRTRKA
IVLCAGDKKGEDEKLFYERMIKIADAEFTSHLISPEVKEDGDA

Download         Length: 372 bp

>T162015 NZ_CP071487:c1192334-1192056 [Glaesserella parasuis]
ATGATTATTTCATTTAAGCATAAAGGATTGAAATTATTTTTTGAAACAGGATCAACCGCAGGTATTCAAGCAAATCACGC
TAGTAAACTTGCTTTTCAATTAGCCACTCTAAACCAAGCAAAAAGTGCTTTAGATATGAATGCACCTAGCTGGAATTTAC
ACCAATTACAAGATAATTTAGCTGGGCATTGGTCTATCAAGGTAAGTGGAAATTGGCGTTTAACTTTTAAATTTCAAAAT
GGTCACGCTGAAGTCGTGGACTATCAAGATTATCATTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11019.09 Da        Isoelectric Point: 10.8728

>AT162015 WP_039294447.1 NZ_CP055224:c26748-26449 [Pectobacterium atrosepticum]
MATLKEMMAKRSPESRARIEARTAEIRQEITLAKLREELKMSQTQLAAALGVKQPSIVKMEKVENDPKLSTLKRYVTALG
GKLTLDVTLPNGKRIALTL

Download         Length: 300 bp

>AT162015 NZ_CP071487:c1192045-1191773 [Glaesserella parasuis]
ATGAAAATGTACAATCCAGCTCACCCAGGGCTTATTTTAAGAGAATATATTGAAGGATATAATGTCACAGAAGTGGCTAA
ACGTTTAGGTGTCACTCGTGTCACGCTCTCTCGTATTTTAAATGGCAAAGCCGCAATTTCACCTGAAATGGCTCTTAGAT
TAAGCCAATTATTAAAAACTAGCCCAGAATTATGGCTTGGTTTACAATCCCAATACGATCTTTGGCAGCTTGAACAACGC
CCAAGTTTTAATATTCAGCCGTTATTTGCATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References