Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 2141432..2142125 Replicon chromosome
Accession NZ_CP055219
Organism Shigella flexneri strain STEFF_12

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag HUZ41_RS10650 Protein ID WP_000415584.1
Coordinates 2141829..2142125 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag HUZ41_RS10645 Protein ID WP_000650107.1
Coordinates 2141432..2141827 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ41_RS10635 (2137296) 2137296..2139554 - 2259 WP_023281485.1 DNA topoisomerase IV subunit A -
HUZ41_RS10640 (2139692) 2139692..2141299 - 1608 WP_239637144.1 ABC transporter substrate-binding protein -
HUZ41_RS10645 (2141432) 2141432..2141827 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
HUZ41_RS10650 (2141829) 2141829..2142125 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
HUZ41_RS10655 (2142330) 2142330..2142812 - 483 WP_000183505.1 GyrI-like domain-containing protein -
HUZ41_RS10660 (2142865) 2142865..2143257 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
HUZ41_RS10665 (2143409) 2143409..2144068 + 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
HUZ41_RS10670 (2144065) 2144065..2145414 + 1350 WP_001618857.1 quorum sensing histidine kinase QseC -
HUZ41_RS10675 (2145460) 2145460..2145792 - 333 WP_000917684.1 DUF2645 family protein -
HUZ41_RS10680 (2146111) 2146111..2146692 + 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
HUZ41_RS10685 (2146723) 2146723..2147037 + 315 WP_000958598.1 putative quinol monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T162004 WP_000415584.1 NZ_CP055219:c2142125-2141829 [Shigella flexneri]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T162004 NZ_CP071464:357539-357886 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTGTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGTGGGCAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT162004 WP_000650107.1 NZ_CP055219:c2141827-2141432 [Shigella flexneri]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT162004 NZ_CP071464:357886-358185 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCTGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References