Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 101680..101933 Replicon plasmid unnamed2
Accession NZ_CP055212
Organism Klebsiella pneumoniae strain STEFF_2

Toxin (Protein)


Gene name srnB Uniprot ID G9G1E3
Locus tag HUZ38_RS27780 Protein ID WP_001312851.1
Coordinates 101784..101933 (+) Length 50 a.a.

Antitoxin (RNA)


Gene name sok
Locus tag -
Coordinates 101680..101739 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ38_RS27755 (98407) 98407..99153 + 747 WP_000205770.1 conjugal transfer pilus acetylase TraX -
HUZ38_RS27760 (99208) 99208..99768 + 561 WP_000139328.1 fertility inhibition protein FinO -
HUZ38_RS27765 (99900) 99900..100100 + 201 WP_015059022.1 hypothetical protein -
HUZ38_RS27770 (100486) 100486..101085 + 600 WP_032083981.1 PIN domain-containing protein -
HUZ38_RS27775 (101147) 101147..101479 + 333 WP_152916585.1 hypothetical protein -
- (101680) 101680..101739 - 60 NuclAT_1 - Antitoxin
- (101680) 101680..101739 - 60 NuclAT_1 - Antitoxin
- (101680) 101680..101739 - 60 NuclAT_1 - Antitoxin
- (101680) 101680..101739 - 60 NuclAT_1 - Antitoxin
HUZ38_RS27780 (101784) 101784..101933 + 150 WP_001312851.1 Hok/Gef family protein Toxin
HUZ38_RS27785 (102217) 102217..102465 + 249 WP_000083837.1 replication regulatory protein RepA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid floR / sul2 / aph(3')-IIa / blaTEM-1B / rmtB / blaCTX-M-55 - 1..102776 102776


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(4-45)


Sequences

Toxin        


Download         Length: 50 a.a.        Molecular weight: 5542.67 Da        Isoelectric Point: 8.7678

>T161956 WP_001312851.1 NZ_CP055212:101784-101933 [Klebsiella pneumoniae]
MTKYALIGLLAVCATVLCFSLIFRERLCELNIHRGNTVVQVTLAYEARK

Download         Length: 150 bp

>T161956 NZ_CP071439:3672608-3672796 [Escherichia coli]
ATGCAATTTACGGTATACCGCAGTCGCGGCAGTAACGCCGCGTTTCCCTTTGTTATCGATGTTACCAGCGACATTATTGG
TGAGATTAATCGCAGTATTGTTATTCCATTAACACCTATTGAACGATTTATCCGTATTCGCCCTCCAGAACGGCTTAACA
CAATCCTTTTACTGGTAGACGGCTCATGA

Antitoxin


Download         Length: 60 bp

>AT161956 NZ_CP055212:c101739-101680 [Klebsiella pneumoniae]
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829C8K5

Antitoxin

Download structure file

References