Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | hok-sok/- |
| Location | 47333..47597 | Replicon | plasmid unnamed3 |
| Accession | NZ_CP055202 | ||
| Organism | Shigella flexneri strain STEFF_3 | ||
Toxin (Protein)
| Gene name | pndA | Uniprot ID | U9Z417 |
| Locus tag | HUZ39_RS25660 | Protein ID | WP_001387489.1 |
| Coordinates | 47445..47597 (+) | Length | 51 a.a. |
Antitoxin (RNA)
| Gene name | pndB | ||
| Locus tag | - | ||
| Coordinates | 47333..47395 (-) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HUZ39_RS25645 (42572) | 42572..44863 | - | 2292 | WP_021497839.1 | F-type conjugative transfer protein TrbC | - |
| HUZ39_RS25650 (44856) | 44856..45926 | - | 1071 | WP_000151583.1 | IncI1-type conjugal transfer protein TrbB | - |
| HUZ39_RS25655 (45945) | 45945..47153 | - | 1209 | WP_000121273.1 | IncI1-type conjugal transfer protein TrbA | - |
| - (47333) | 47333..47395 | - | 63 | NuclAT_0 | - | Antitoxin |
| - (47333) | 47333..47395 | - | 63 | NuclAT_0 | - | Antitoxin |
| - (47333) | 47333..47395 | - | 63 | NuclAT_0 | - | Antitoxin |
| - (47333) | 47333..47395 | - | 63 | NuclAT_0 | - | Antitoxin |
| HUZ39_RS25660 (47445) | 47445..47597 | + | 153 | WP_001387489.1 | Hok/Gef family protein | Toxin |
| HUZ39_RS25665 (47669) | 47669..47920 | - | 252 | WP_001291964.1 | hypothetical protein | - |
| HUZ39_RS26135 (48419) | 48419..48514 | + | 96 | WP_001303310.1 | DinQ-like type I toxin DqlB | - |
| HUZ39_RS25675 (48579) | 48579..48755 | - | 177 | WP_001054900.1 | hypothetical protein | - |
| HUZ39_RS25680 (49087) | 49087..49296 | + | 210 | WP_000062602.1 | HEAT repeat domain-containing protein | - |
| HUZ39_RS25685 (49368) | 49368..50030 | - | 663 | WP_000644792.1 | plasmid IncI1-type surface exclusion protein ExcA | - |
| HUZ39_RS25690 (50095) | 50095..52263 | - | 2169 | WP_077250315.1 | DotA/TraY family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | blaCTX-M-24 | - | 1..91691 | 91691 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 51 a.a. Molecular weight: 5761.10 Da Isoelectric Point: 8.7948
>T161926 WP_001387489.1 NZ_CP055202:47445-47597 [Shigella flexneri]
MPQRTFLMMLIVVCVTILCFVWMVRDSLCGLRLQQGNTVLVATLAYEVKR
MPQRTFLMMLIVVCVTILCFVWMVRDSLCGLRLQQGNTVLVATLAYEVKR
Download Length: 153 bp
>T161926 NZ_CP071436:1749788-1750039 [Escherichia coli]
ATGCGTACAATTAGTTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
TCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA
ATGCGTACAATTAGTTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
TCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA
Antitoxin
Download Length: 63 bp
>AT161926 NZ_CP055202:c47395-47333 [Shigella flexneri]
TCGAAGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT
TCGAAGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
